AIMC Topic: Spectrometry, Fluorescence
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Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Talanta
Nov 22, 2017
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
Modification-free carbon dots as turn-on fluorescence probe for detection of organophosphorus pesticides.
Food chemistry
Nov 11, 2017
It is important to detect pesticides residues due to the concern over food safety. In this work, the burning ash of waste paper was used as carbon source to synthesize carbon dots (C-dots). The fluorescence of obtained C-dots could been turn off by F...
A hierarchical classifier based on human blood plasma fluorescence for non-invasive colorectal cancer screening.
Artificial intelligence in medicine
Sep 20, 2017
Colorectal cancer (CRC) a leading cause of death by cancer, and screening programs for its early identification are at the heart of the increasing survival rates. To motivate population participation, non-invasive, accurate, scalable and cost-effecti...
Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and spiked human plasma: Application to degradation kinetics.
Journal of food and drug analysis
Jul 8, 2017
Based on investigating the relative fluorescence intensity of vancomycin hydrochloride (VCM) in methanol, a simple, highly sensitive, time-saving and specific spectrofluorimetric method was developed and validated. VCM fluorescence was measured at 33...
Sensitive fluorescent detection of DNA methyltransferase using nicking endonuclease-mediated multiple primers-like rolling circle amplification.
Biosensors & bioelectronics
Dec 30, 2016
Sensitive and reliable detection of DNA methyltransferase (MTase) is of great significance for both early tumor diagnosis and therapy. In this study, a simple, label-free and sensitive DNA MTase-sensing method was developed on the basis of a nicking ...
Oil species identification technique developed by Gabor wavelet analysis and support vector machine based on concentration-synchronous-matrix-fluorescence spectroscopy.
Marine pollution bulletin
Jan 13, 2016
Concentration-synchronous-matrix-fluorescence (CSMF) spectroscopy was applied to discriminate the oil species by characterizing the concentration dependent fluorescence properties of petroleum related samples. Seven days weathering experiment of 3 cr...
Application of unfolded principal component analysis-radial basis function neural network for determination of celecoxib in human serum by three-dimensional excitation-emission matrix fluorescence spectroscopy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Dec 8, 2014
This study describes a simple and rapid approach of monitoring celecoxib (CLX). Unfolded principal component analysis-radial basis function neural network (UPCA-RBFNN) and excitation-emission spectra were combined to develop new model in the determin...
Dual-mode nanosensor for sensitive detection of methotrexate based on fluorescence technology and deep learning algorithms.
Analytica chimica acta
Aug 8, 2025
BACKGROUND: Methotrexate (MTX) in the body can result in severe, potentially life-threatening side effects. As a result, it is imperative to establish a dependable, precise, and specific method for detecting MTX. However, conventional sensors often s...
Rapid diagnosis of lung cancer by multi-modal spectral data combined with deep learning.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 5, 2025
Lung cancer is a malignant tumor that poses a serious threat to human health. Existing lung cancer diagnostic techniques face the challenges of high cost and slow diagnosis. Early and rapid diagnosis and treatment are essential to improve the outcome...
Deep Learning-Assisted Nanocavity Sensor for Amphiphilic Biomarker Analysis.
Analytical chemistry
Jul 1, 2025
Fluorescence enhancement using nanocavity structures is a promising approach for rapid detection of amphiphilic biomarkers, which are essential for diagnosing diseases such as cancer and infections. This paper presents the use of a silver nanocube (A...
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