AIMC Topic: Spinal Cord

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A pipeline to quantify spinal cord atrophy with deep learning: Application to differentiation of MS and NMOSD patients.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
PURPOSE: Quantitative measurement of various anatomical regions of the brain and spinal cord (SC) in MRI images are used as unique biomarkers to consider progress and effects of demyelinating diseases of the central nervous system. This paper present...

Automatic multiclass intramedullary spinal cord tumor segmentation on MRI with deep learning.

NeuroImage. Clinical
Spinal cord tumors lead to neurological morbidity and mortality. Being able to obtain morphometric quantification (size, location, growth rate) of the tumor, edema, and cavity can result in improved monitoring and treatment planning. Such quantificat...

The CPGs for Limbed Locomotion-Facts and Fiction.

International journal of molecular sciences
The neuronal networks that generate locomotion are well understood in swimming animals such as the lamprey, zebrafish and tadpole. The networks controlling locomotion in tetrapods remain, however, still enigmatic with an intricate motor pattern requi...

Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.

Frontiers in neural circuits
The mechanisms involved in generation of rhythmic locomotor activity in the mammalian spinal cord remain poorly understood. These mechanisms supposedly rely on both intrinsic properties of constituting neurons and interactions between them. A subset ...

Automatic segmentation of pelvic organs-at-risk using a fusion network model based on limited training samples.

Acta oncologica (Stockholm, Sweden)
Efficient and accurate methods are needed to automatically segmenting organs-at-risk (OAR) to accelerate the radiotherapy workflow and decrease the treatment wait time. We developed and evaluated the use of a fused model Dense V-Network for its abil...

Robot controlled, continuous passive movement of the ankle reduces spinal cord excitability in participants with spasticity: a pilot study.

Experimental brain research
Spasticity of the ankle reduces quality of life by impeding walking and other activities of daily living. Robot-driven continuous passive movement (CPM) is a strategy for lower limb spasticity management but effects on spasticity, walking ability and...

Open-source pipeline for multi-class segmentation of the spinal cord with deep learning.

Magnetic resonance imaging
This paper presents an open-source pipeline to train neural networks to segment structures of interest from MRI data. The pipeline is tailored towards homogeneous datasets and requires relatively low amounts of manual segmentations (few dozen, or les...

A supervised machine learning approach to characterize spinal network function.

Journal of neurophysiology
Spontaneous activity is a common feature of immature neuronal networks throughout the central nervous system and plays an important role in network development and consolidation. In postnatal rodents, spontaneous activity in the spinal cord exhibits ...

Spinal cord detection in planning CT for radiotherapy through adaptive template matching, IMSLIC and convolutional neural networks.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: The spinal cord is a very important organ that must be protected in treatments of radiotherapy (RT), considered an organ at risk (OAR). Excess rays associated with the spinal cord can cause irreversible diseases in patients ...

Afferent Input Induced by Rhythmic Limb Movement Modulates Spinal Neuronal Circuits in an Innovative Robotic In Vitro Preparation.

Neuroscience
Locomotor patterns are mainly modulated by afferent feedback, but its actual contribution to spinal network activity during continuous passive limb training is still unexplored. To unveil this issue, we devised a robotic in vitro setup (Bipedal Induc...