AIMC Topic: STAT3 Transcription Factor

Clear Filters Showing 11 to 16 of 16 articles

Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 31, 2023
The objective of this study was to investigate the improvement effect of Astragalus (AS) extract on oxidative stress (OS) and inflammatory response of myocarditis (MYO) cells through the STAT3/IL-6 axis. For this purpose, The MYO model cells prepared...
Apoptosis Interleukin-6 STAT3 Transcription Factor Myocarditis Oxidative Stress Inflammation Humans Cytokines
View on PubMed DOI

A novel artificial intelligence protocol for finding potential inhibitors of acute myeloid leukemia.

Journal of materials chemistry. B Feb 18, 2020
There is currently no effective treatment for acute myeloid leukemia, and surgery is also ineffective as an important treatment for most tumors. Rapidly developing artificial intelligence technology can be applied to different aspects of drug develop...
Artificial Intelligence Machine Learning Leukemia, Myeloid, Acute Humans STAT3 Transcription Factor Ligands Databases, Chemical Drug Discovery Protein Binding Molecular Dynamics Simulation
View on PubMed DOI

Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.

Drug and chemical toxicology Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
Cell Line Salmonella typhimurium STAT3 Transcription Factor Anthraquinones Micronucleus Tests Mutagenicity Tests Antineoplastic Agents Mice Cell Culture Techniques Dose-Response Relationship, Drug Macrophages Micronuclei, Chromosome-Defective Animals
View on PubMed DOI

Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Arteriosclerosis, thrombosis, and vascular biology Mar 10, 2016
OBJECTIVE: Recent genome-wide association studies of coronary artery disease (CAD) have revealed 58 genome-wide significant and 148 suggestive genetic loci. However, the molecular mechanisms through which they contribute to CAD and the clinical impli...
Neural Networks, Computer Phenotype Computer Simulation Humans Genome-Wide Association Study Protein Interaction Maps Gene Regulatory Networks Animals Gene Expression Profiling Case-Control Studies Lumican Databases, Genetic Bayes Theorem Coronary Artery Disease STAT3 Transcription Factor Genetic Loci Gene Expression Regulation Genetic Predisposition to Disease Computational Biology Mice Signal Transduction Genomics
View on PubMed DOI

[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
Synovial Membrane Humans Fibroblasts Cells, Cultured Interleukins Arthritis, Rheumatoid Cell Proliferation Synoviocytes Phosphorylation Tyrphostins STAT3 Transcription Factor Interleukin-22 MAP Kinase Signaling System
View on PubMed DOI

[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2016
To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon cancer.
 Methods: Crude extract was obtained from JPJD by water extract method. The effect of JPJD crude extract on colon cancer ce...
Sphingomyelin Phosphodiesterase Up-Regulation Cathepsin B Cathepsins Hypoxia-Inducible Factor 1, alpha Subunit Integrin alpha Chains Receptors, Urokinase Plasminogen Activator Neovascularization, Pathologic Tumor Suppressor Protein p53 Down-Regulation STAT3 Transcription Factor Vascular Endothelial Growth Factor A Gene Expression Profiling Cell Line, Tumor Signal Transduction Drugs, Chinese Herbal Blotting, Western TOR Serine-Threonine Kinases Humans Colorectal Neoplasms Animals
View on PubMed DOI
Popular Topics
Recent Journals