AIMC Topic: Substantia Nigra
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Quantitative susceptibility mapping based hybrid feature extraction for diagnosis of Parkinson's disease.
NeuroImage. Clinical
Nov 5, 2019
Parkinson's disease is the second most common neurodegenerative disease in the elderly after Alzheimer's disease. The aetiology and pathogenesis of Parkinson's disease (PD) are still unclear, but the loss of dopaminergic cells and the excessive iron ...
Predictive markers for Parkinson's disease using deep neural nets on neuromelanin sensitive MRI.
NeuroImage. Clinical
Mar 6, 2019
Neuromelanin sensitive magnetic resonance imaging (NMS-MRI) has been crucial in identifying abnormalities in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) as PD is characterized by loss of dopaminergic neurons in the SNc. Curre...
Implementation of deep neural networks to count dopamine neurons in substantia nigra.
The European journal of neuroscience
Sep 20, 2018
Unbiased estimates of neuron numbers within substantia nigra are crucial for experimental Parkinson's disease models and gene-function studies. Unbiased stereological counting techniques with optical fractionation are successfully implemented, but ar...
Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery.
Movement disorders : official journal of the Movement Disorder Society
Oct 6, 2016
BACKGROUND: Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery for Parkinson's disease. Usually, the demarcation of the S...
Automatic substantia nigra segmentation in neuromelanin-sensitive MRI by deep neural network in patients with prodromal and manifest synucleinopathy.
Physiological research
Dec 30, 2019
Neuromelanin (NM) is a black pigment located in the brain in substantia nigra pars compacta (SN) and locus coeruleus. Its loss is directly connected to the loss of nerve cells in this part of the brain, which plays a role in Parkinson's Disease. Magn...
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
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