Computer methods and programs in biomedicine
Oct 12, 2017
BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine design. Epitopes or antigenic peptides are a set of amino acids that bind with the Major Histocompati...
Swarm robotics is concerned with the decentralised coordination of multiple robots having only limited communication and interaction abilities. Although fault tolerance and robustness to individual robot failures have often been used to justify the u...
Clinical nutrition (Edinburgh, Scotland)
Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
The immune system has evolved to make a diverse repertoire of peptides processed from self and foreign proteomes, which are displayed in antigen-binding grooves of major histocompatibility complex (MHC) proteins at cell surface for surveillance by T ...
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the therapeutic landscape for relapsed or refractory lymphoid malignancies, achieving remarkable rates of durable remission. Despite this success, significant variability among patient...
Cell therapies like Chimeric Antigen Receptor (CAR)-T cell therapy deliver living cells to patients as active pharmaceutical ingredients. Manufacturing of these cells is complex, often yielding, heterogeneous products and high failure rates. Quality ...
Protein science : a publication of the Protein Society
Aug 1, 2025
Within the central nervous system, the myelin sheath is composed of elements known as myelin autoantigens that are mistakenly targeted by the immune system in multiple sclerosis (MS). This autoimmune attack leads to the destruction of myelin, resulti...
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: T cells play a vital role in the immune system by recognizing and eliminating infected or cancerous cells, thus driving adaptive immune responses. Their activation is triggered by the binding of T cell receptors (TCRs) to ep...
Cellular senescence is a complex biological process with a dual role in tissue homeostasis and aging-related pathologies. Accumulation of senescent cells promotes chronic inflammation, tissue dysfunction, age-related diseases, and tumor suppression. ...
Journal of biomolecular structure & dynamics
May 1, 2025
Hematopoietic progenitor kinase 1 (HPK1) is a key negative regulator of T-cell receptor (TCR) signaling and a promising target for cancer immunotherapy. The development of novel HPK1 inhibitors is challenging yet promising. In this study, we used a c...
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