AIMC Topic: Tandem Mass Spectrometry
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Accurate analysis of parabens in human urine using isotope-dilution ultrahigh-performance liquid chromatography-high resolution mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 24, 2017
An analytical method that utilizes isotope-dilution ultrahigh-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS or called UHPLC-HRMS) was developed, and validated to be highly precise and...
Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 21, 2017
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surf...
Pseudomonas aeruginosa
Solid Phase Extraction
Hydrolysis
Animals, Genetically Modified
Calibration
Reference Standards
Cytochrome P450 Family 7
Oxysterols
Male
Chromatography, Liquid
Bacterial Proteins
Tandem Mass Spectrometry
Humans
Reproducibility of Results
Animals
Rats, Inbred F344
Steroid Hydroxylases
Sterol Esterase
Simultaneous quantification of fluoxetine and norfluoxetine in colostrum and mature human milk using a 2-dimensional liquid chromatography-tandem mass spectrometry system.
Journal of pharmaceutical and biomedical analysis
Dec 20, 2017
A two-dimensional liquid chromatography system coupled to triple quadrupole tandem mass spectrometer (2D LC-MS/MS) was employed for the determination of fluoxetine (FLU) and norfluoxetine (N-FLU) in colostrum and mature milk by direct sample injectio...
Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.
Talanta
Dec 16, 2017
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation pr...
Bionalytical validation study for the determination of unbound ambrisentan in human plasma using rapid equilibrium dialysis followed by ultra performance liquid chromatography coupled to mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 16, 2017
Ambrisentan is a highly selective endothelin-1 type A receptor antagonist indicated for use in the treatment of pulmonary hypertension. In this study an assay was developed and validated for the quantification of total and unbound (free) concentratio...
Simultaneous determination of Vitamin A, 25-hydroxyl vitamin D α-tocopherol in small biological fluids by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 15, 2017
A sensitive method for the simultaneous analysis of vitamin A (VA), 25-hydroxyl vitamin D (25-OH VD) and α-tocopherol (VE) in children plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and validated. Sample prepar...
Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.
Journal of pharmaceutical and biomedical analysis
Dec 15, 2017
LNA-i-miR-221, a 13-mer oligonucleotide, is a new miR-221 inhibitor that could be used as a novel drug for multiple myeloma. Herein, an ion-pair reversed phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and va...
UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 12, 2017
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic D...
Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring.
Tuberculosis (Edinburgh, Scotland)
Nov 24, 2017
First-line anti-tuberculosis drugs are playing vital roles for curbing rapid spread of tuberculosis. Multidrug therapies are commonly applied in clinical to achieve better treatment outcomes. However, drug resistance and adverse reactions come along ...
pDeep: Predicting MS/MS Spectra of Peptides with Deep Learning.
Analytical chemistry
Nov 21, 2017
In tandem mass spectrometry (MS/MS)-based proteomics, search engines rely on comparison between an experimental MS/MS spectrum and the theoretical spectra of the candidate peptides. Hence, accurate prediction of the theoretical spectra of peptides ap...
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