AIMC Topic: Tandem Mass Spectrometry
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Simultaneous quantitative determination of bioactive terpene indole alkaloids in ethanolic extracts of Catharanthus roseus (L.) G. Don by ultra high performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 25, 2017
A rapid, sensitive and reproducible method using ultra-high-performance liquid chromatography coupled with electrospray ionization hybrid triple quadrupole-linear ion trap mass spectrometry (UHPLC-ESI-QqQ-MS/MS) in multiple reaction monitoring (MRM) ...
[Identification of Methamphetamine Abuse and Selegiline Use： Chiral Analysis of Methamphetamine and Amphetamine in Urine].
Fa yi xue za zhi
Dec 25, 2017
OBJECTIVES: To study the content variation of selegiline and its metabolites in urine, and based on actual cases, to explore the feasibility for the identification of methamphetamine abuse and selegiline use by chiral analysis.
LC-MS/MS method for simultaneous determination of diethylcarbamazine, albendazole and albendazole metabolites in human plasma: Application to a clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis
Dec 24, 2017
Combination therapy with anti-filarial drugs is now widely used for treatment of lymphatic filariasis. A rapid, selective, and sensitive liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed and validated for sim...
Accurate analysis of parabens in human urine using isotope-dilution ultrahigh-performance liquid chromatography-high resolution mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 24, 2017
An analytical method that utilizes isotope-dilution ultrahigh-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS or called UHPLC-HRMS) was developed, and validated to be highly precise and...
Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 21, 2017
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surf...
Steroid Hydroxylases
Sterol Esterase
Chromatography, Liquid
Solid Phase Extraction
Humans
Hydrolysis
Reproducibility of Results
Animals, Genetically Modified
Animals
Calibration
Bacterial Proteins
Male
Tandem Mass Spectrometry
Pseudomonas aeruginosa
Reference Standards
Cytochrome P450 Family 7
Oxysterols
Rats, Inbred F344
Simultaneous quantification of fluoxetine and norfluoxetine in colostrum and mature human milk using a 2-dimensional liquid chromatography-tandem mass spectrometry system.
Journal of pharmaceutical and biomedical analysis
Dec 20, 2017
A two-dimensional liquid chromatography system coupled to triple quadrupole tandem mass spectrometer (2D LC-MS/MS) was employed for the determination of fluoxetine (FLU) and norfluoxetine (N-FLU) in colostrum and mature milk by direct sample injectio...
Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.
Talanta
Dec 16, 2017
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation pr...
Bionalytical validation study for the determination of unbound ambrisentan in human plasma using rapid equilibrium dialysis followed by ultra performance liquid chromatography coupled to mass spectrometry.
Journal of pharmaceutical and biomedical analysis
Dec 16, 2017
Ambrisentan is a highly selective endothelin-1 type A receptor antagonist indicated for use in the treatment of pulmonary hypertension. In this study an assay was developed and validated for the quantification of total and unbound (free) concentratio...
Simultaneous determination of Vitamin A, 25-hydroxyl vitamin D α-tocopherol in small biological fluids by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 15, 2017
A sensitive method for the simultaneous analysis of vitamin A (VA), 25-hydroxyl vitamin D (25-OH VD) and α-tocopherol (VE) in children plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and validated. Sample prepar...
Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.
Journal of pharmaceutical and biomedical analysis
Dec 15, 2017
LNA-i-miR-221, a 13-mer oligonucleotide, is a new miR-221 inhibitor that could be used as a novel drug for multiple myeloma. Herein, an ion-pair reversed phase liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and va...
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