AIMC Topic: Tandem Mass Spectrometry

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Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry.

Talanta Dec 29, 2015
Estrogens circulate at concentrations less than 20pg/mL in men and postmenopausal women, presenting analytical challenges. Quantitation by immunoassay is unreliable at these low concentrations. Liquid chromatography tandem mass spectrometry (LC-MS/MS...
Benzenesulfonates Male Estrone Middle Aged Aged Postmenopause Estradiol Aged, 80 and over Pyridinium Compounds Humans Chromatography, Liquid Estrogens Young Adult Premenopause Female Tandem Mass Spectrometry Adult Reproducibility of Results Solid Phase Extraction Spectrometry, Mass, Electrospray Ionization
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A simple and sensitive UHPLC-MS/MS method for quantification of buddlejasaponin IV in rat plasma and its application to a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis Dec 29, 2015
Buddlejasaponin IV (BS-IV), a natural triterpene saponin isolated from several herbal plants, has drawn a lot of attention for its anti-inflammatory, antinociceptive, antihyperlipidemia, and antitumor activities. In this study, a simple and sensitive...
Administration, Oral Saponins Dose-Response Relationship, Drug Triterpenes Chromatography, High Pressure Liquid Tandem Mass Spectrometry Male Rats, Wistar Rats Animals
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Quantitation of anacetrapib, stable-isotope labeled-anacetrapib (microdose), and four metabolites in human plasma using liquid chromatography tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 29, 2015
An ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of (4S,5R)-5-[3,5-bis (trifluoromethyl)phenyl]-3-{[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl] met...
Humans Reproducibility of Results Sensitivity and Specificity Chromatography, Liquid Tandem Mass Spectrometry Biological Availability Linear Models Oxazolidinones Isotope Labeling
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Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry - Method validation and its application to clinical samples.

Journal of pharmaceutical and biomedical analysis Dec 22, 2015
A sensitive and specific method was developed and validated for the quantitation of maytansinoid (DM1) in human serum using on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS). Because DM1 contains a free th...
Infusions, Intravenous Tandem Mass Spectrometry Solid Phase Extraction Maytansine Humans Reproducibility of Results Neoplasms Chromatography, Liquid
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Simultaneous determination and pharmacokinetics of five alkaloids in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry after the oral administration of Corydalis bungeana Turcz extract.

Journal of separation science Nov 26, 2015
Pharmacokinetic studies were conducted on rats for protopine, corynoline, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)-ethyl]propenamide, acetylcorynoline, and 8-oxocorynoline, five main active components from Corydalis bungeana Turcz (C. bungeana...
Animals Male Tandem Mass Spectrometry Rats Alkaloids Rats, Sprague-Dawley Corydalis Drugs, Chinese Herbal Chromatography, High Pressure Liquid
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Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.

Scientific reports Nov 18, 2015
Endogenous ribonucleotides and deoxyribonucleotides are essential metabolites that play important roles in a broad range of key cellular functions. Their intracellular levels could also reflect the action of nucleoside analogues. We investigated the ...
Metabolic Networks and Pathways Models, Biological Fluorouracil Tandem Mass Spectrometry Humans Neural Networks, Computer Hep G2 Cells Guanine Nucleotides Cell Survival Inhibitory Concentration 50 Ribonucleotides Chromatography, Liquid Adenine Nucleotides Thymine Nucleotides Cytosine Nucleotides Uracil Nucleotides Deoxyribonucleotides
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Chemometrics for comprehensive analysis of nucleobases, nucleosides, and nucleotides in Siraitiae Fructus by hydrophilic interaction ultra high performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry.

Journal of separation science Sep 10, 2015
A rapid and sensitive hydrophilic interaction ultra high performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry method was validated for the simultaneous determination of 20 nucleobases, nucleosides,...
Nucleosides Chromatography, High Pressure Liquid Tandem Mass Spectrometry Fruit Nucleotides Ions Hydrophobic and Hydrophilic Interactions Neural Networks, Computer Cluster Analysis Principal Component Analysis Drugs, Chinese Herbal
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Comparative evaluation of different cultivars of Flos Chrysanthemi by an anti-inflammatory-based NF-κB reporter gene assay coupled to UPLC-Q/TOF MS with PCA and ANN.

Journal of ethnopharmacology Aug 29, 2015
ETHNOPHARMACOLOGICAL RELEVANCE: Flos Chrysanthemi (FC), a commonly used traditional Chinese medicine, has five major cultivars ("Boju", "Chuju", "Gongju", "Hangbaiju" and "Huaiju") from different sources. However, the active constituents of these cul...
Anti-Inflammatory Agents Drug Evaluation, Preclinical Chromatography, High Pressure Liquid Tandem Mass Spectrometry Humans Neural Networks, Computer Principal Component Analysis NF-kappa B HEK293 Cells Genes, Reporter Chrysanthemum
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Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

Proteomics Jun 11, 2015
With growing abundance and awareness of endocrine disrupting compounds (EDCs) in the environment, there is a need for accurate and reliable detection of EDC exposure. Our objective in the present study was to observe differences within and between th...
Fish Proteins Bass Kininogens Vitellogenins Tandem Mass Spectrometry Nanotechnology Sex Factors Estradiol Estrogens Proteomics Proteome Support Vector Machine Chromatography, Liquid Blood Proteins Blotting, Western Female Animals Male
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Prediction of overall in vitro microsomal stability of drug candidates based on molecular modeling and support vector machines. Case study of novel arylpiperazines derivatives.

PloS one Mar 31, 2015
Other than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach i...
Microsomes Tandem Mass Spectrometry Spectrometry, Mass, Electrospray Ionization Half-Life Support Vector Machine Chromatography, Liquid Models, Molecular Piperazines
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