AIMC Topic: Telomerase
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Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.
Scientific reports
May 27, 2025
Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. Thi...
Detecting IDH and TERTp mutations in diffuse gliomas using H-MRS with attention deep-shallow networks.
Computers in biology and medicine
Jan 27, 2025
BACKGROUND: Preoperative and noninvasive detection of isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase gene promoter (TERTp) mutations in glioma is critical for prognosis and treatment planning. This study aims to develop deep lear...
Evaluating the prognostic potential of telomerase signature in breast cancer through advanced machine learning model.
Frontiers in immunology
Nov 28, 2024
BACKGROUND: Breast cancer prognosis remains a significant challenge due to the disease's molecular heterogeneity and complexity. Accurate predictive models are critical for improving patient outcomes and tailoring personalized therapies.
Predicting telomerase reverse transcriptase promoter mutation in glioma: A systematic review and diagnostic meta-analysis on machine learning algorithms.
The neuroradiology journal
Aug 5, 2024
BackgroundGlioma is one of the most common primary brain tumors. The presence of the telomerase reverse transcriptase promoter (pTERT) mutation is associated with a better prognosis. This study aims to investigate the TERT mutation in patients with g...
Using deep learning to decipher the impact of telomerase promoter mutations on the dynamic metastatic morpholome.
PLoS computational biology
Jul 30, 2024
Melanoma showcases a complex interplay of genetic alterations and intra- and inter-cellular morphological changes during metastatic transformation. While pivotal, the role of specific mutations in dictating these changes still needs to be fully eluci...
Deep Learning Radiomics for the Assessment of Telomerase Reverse Transcriptase Promoter Mutation Status in Patients With Glioblastoma Using Multiparametric MRI.
Journal of magnetic resonance imaging : JMRI
Mar 10, 2023
BACKGROUND: Studies have shown that magnetic resonance imaging (MRI)-based deep learning radiomics (DLR) has the potential to assess glioma grade; however, its role in predicting telomerase reverse transcriptase (TERT) promoter mutation status in pat...
Deep Learning Prediction of Promoter Mutation Status in Thyroid Cancer Using Histologic Images.
Medicina (Kaunas, Lithuania)
Mar 9, 2023
objectives: Telomerase reverse transcriptase () promoter mutation, found in a subset of patients with thyroid cancer, is strongly associated with aggressive biologic behavior. Predicting promoter mutation is thus necessary for the prognostic strati...
Application of machine learning to large in-vitro databases to identify cancer cell characteristics: telomerase reverse transcriptase (TERT) expression.
Oncogene
Jun 16, 2021
Advances in biotechnology and machine learning have created an enhanced environment for unearthing and exploiting previously unrecognized relationships between genomic and epigenetic data with potential therapeutic implications. We applied advanced a...
Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network.
Scientific reports
Dec 30, 2019
Identification of genotypes is crucial for treatment of glioma. Here, we developed a method to predict tumor genotypes using a pretrained convolutional neural network (CNN) from magnetic resonance (MR) images and compared the accuracy to that of a di...
Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.
Nucleic acids research
Feb 22, 2016
Understanding telomere length maintenance mechanisms is central in cancer biology as their dysregulation is one of the hallmarks for immortalization of cancer cells. Important for this well-balanced control is the transcriptional regulation of the te...
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