AIMC Topic: Tissue Scaffolds
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iPSC-RPE patch restores photoreceptors and regenerates choriocapillaris in a pig retinal degeneration model.
JCI insight
May 22, 2025
Dry age-related macular degeneration (AMD) is a leading cause of untreatable vision loss. In advanced cases, retinal pigment epithelium (RPE) cell loss occurs alongside photoreceptor and choriocapillaris degeneration. We hypothesized that an RPE-patc...
Optimal structural characteristics of osteoinductivity in bioceramics derived from a novel high-throughput screening plus machine learning approach.
Biomaterials
Apr 16, 2025
Osteoinduction is an important feature of the next generation of bone repair materials. But the key structural factors and parameters of osteoinductive scaffolds are not yet clarified. This study leverages the efficiency of high-throughput screening ...
Surrogate modeling of electrospun PVA/PLA nanofibers using artificial neural network for biomedical applications.
Scientific reports
Apr 15, 2025
Blending poly (lactic acid) (PLA) with poly (vinyl alcohol) (PVA) improves the strength and hydrophilicity of nanofibers, making them suitable for biomedical applications like wound dressings. This study explores how electrospinning parameters-applie...
Predicting inflammatory response of biomimetic nanofibre scaffolds for tissue regeneration using machine learning and graph theory.
Journal of materials chemistry. B
Mar 5, 2025
Tissue regeneration after a wound occurs through three main overlapping and interrelated stages namely inflammatory, proliferative, and remodelling phases, respectively. The inflammatory phase is key for successful tissue reconstruction and triggers ...
Design and optimization of tamarind seed polysaccharide-based scaffold for tissue engineering applications using statistical modeling and machine learning, and it's in-vitro validation.
International journal of biological macromolecules
Jan 30, 2025
This study explores the development and optimization of a novel biomaterial scaffold for tissue engineering, composed of Tamarind seed polysaccharide (TSP), Hydroxypropyl methylcellulose (HPMC), Chitosan (CS), and Sodium alginate (ALG). Scaffold prop...
Functional antimicrobial peptide-loaded 3D scaffolds for infected bone defect treatment with AI and multidimensional printing.
Materials horizons
Jan 2, 2025
Infection is the most prevalent complication of fractures, particularly in open fractures, and often leads to severe consequences. The emergence of bacterial resistance has significantly exacerbated the burden of infection in clinical practice, makin...
3D Bioprinting and Artificial Intelligence-Assisted Biofabrication of Personalized Oral Soft Tissue Constructs.
Advanced healthcare materials
Dec 17, 2024
Regeneration of oral soft tissue defects, including mucogingival defects associated with the recession or loss of gingival and/or mucosal tissues around teeth and implants, is crucial for restoring oral tissue form, function, and health. This study p...
3D Printing of a Biomimetic Myotendinous Junction Assisted by Artificial Intelligence.
Biomaterials science
Nov 19, 2024
The myotendinous junction (MTJ) facilitates force transmission between muscle and tendon to produce joint movement. The complex microarchitecture and regional mechanical heterogeneity of the myotendinous junction pose major challenges in creating thi...
Prediction of directional solidification in freeze casting of biomaterial scaffolds using physics-informed neural networks.
Biomedical physics & engineering express
Sep 20, 2024
Freeze casting, a manufacturing technique widely applied in biomedical fields for fabricating biomaterial scaffolds, poses challenges for predicting directional solidification due to its highly nonlinear behavior and complex interplay of process para...
Predicting ultrasound wave stimulated bone growth in bioinspired scaffolds using machine learning.
Journal of the mechanical behavior of biomedical materials
Aug 14, 2024
For conditions like osteoporosis, changes in bone pore geometry even when porosity is constant have been shown to correlate to increased fracture risk using techniques such as dual-energy x-ray absorptiometry (DXA) and computed tomography (CT). Addit...
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