AIMC Topic: Tuberculosis
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Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I.
Tuberculosis (Edinburgh, Scotland)
Jan 20, 2017
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Molecular Targeted Therapy
Protein Conformation
Mycobacterium smegmatis
DNA Topoisomerases, Type I
Topoisomerase I Inhibitors
Bayes Theorem
Antitubercular Agents
Tuberculosis
Mycobacterium tuberculosis
Drug Design
Dose-Response Relationship, Drug
Structure-Activity Relationship
Humans
Machine Learning
Molecular Docking Simulation
Computer-Aided Design
Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).
Journal of chemical information and modeling
Jul 1, 2016
The renewed urgency to develop new treatments for Mycobacterium tuberculosis (Mtb) infection has resulted in large-scale phenotypic screening and thousands of new active compounds in vitro. The next challenge is to identify candidates to pursue in a ...
An Imbalanced Learning based MDR-TB Early Warning System.
Journal of medical systems
May 21, 2016
As a man-made disease, multidrug-resistant tuberculosis (MDR-TB) is mainly caused by improper treatment programs and poor patient supervision, most of which could be prevented. According to the daily treatment and inspection records of tuberculosis (...
Genomics and Machine Learning for Taxonomy Consensus: The Mycobacterium tuberculosis Complex Paradigm.
PloS one
Jul 8, 2015
Infra-species taxonomy is a prerequisite to compare features such as virulence in different pathogen lineages. Mycobacterium tuberculosis complex taxonomy has rapidly evolved in the last 20 years through intensive clinical isolation, advances in sequ...
Molecular Epidemiology
Genomics
DNA, Bacterial
Machine Learning
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Databases, Genetic
Internet
Algorithms
Genotype
Cluster Analysis
Tuberculosis
Prevalence
Computational Biology
Mycobacterium tuberculosis
Polymerase Chain Reaction
Bacterial Typing Techniques
A tuberculosis ontology for host systems biology.
Tuberculosis (Edinburgh, Scotland)
Jun 30, 2015
A major hurdle facing tuberculosis (TB) investigators who want to utilize a rapidly growing body of data from both systems biology approaches and omics technologies is the lack of a standard vocabulary for data annotation and reporting. Lacking a mea...
RAIRS2 a new expert system for diagnosing tuberculosis with real-world tournament selection mechanism inside artificial immune recognition system.
Medical & biological engineering & computing
Jun 17, 2015
Tuberculosis is a major global health problem that has been ranked as the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus. Diagnosis based on cultured specimens is the reference standard; how...
Use of a convolutional neural network for direct detection of acid-fast bacilli from clinical specimens.
Microbiology spectrum
Aug 5, 2025
Mycobacteria, including (MTB) and non-tuberculosis mycobacteria (NTM), are important causes of infectious disease and cause significant mortality and morbidity globally. Fast detection is extremely important to reduce transmission and mortality asso...
Multiomics and Machine Learning Identify Immunometabolic Biomarkers for Active Tuberculosis Diagnosis Against Nontuberculous Mycobacteria and Latent Tuberculosis Infection.
Journal of proteome research
Aug 1, 2025
This study utilized multiomics combined with a comprehensive machine learning-based predictive modeling approach to identify, validate, and prioritize circulating immunometabolic biomarkers in distinguishing tuberculosis (TB) from nontuberculous myco...
[Tongue swabs: a novel tool for tuberculosis screening].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Jul 12, 2025
Tuberculosis (TB) remains a significant global public health threat. Achieving the 2035 target for TB elimination requires interrupting its community transmission, which depends critically on enhancing case detection. Active screening for TB in commu...
[Serum proteomics and machine learning unveil new diagnostic biomarkers for tuberculosis in adolescents and young adults].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Apr 25, 2025
Adolescents and young adults (AYAs) are one of the major populations susceptible to tuberculosis. However, little is known about the unique characteristics and diagnostic biomarkers of tuberculosis in this population. In this study, 81 AYAs were recr...
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