MOTIVATION: As part of the NIH Library of Integrated Network-based Cellular Signatures program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20 000 sma...
Investigative ophthalmology & visual science
Jun 1, 2018
PURPOSE: To apply computational techniques to wide-angle swept-source optical coherence tomography (SS-OCT) images to identify novel, glaucoma-related structural features and improve detection of glaucoma and prediction of future glaucomatous progres...
PURPOSE OF REVIEW: To review current practices and technologies within the scope of "Big Data" that can further our understanding of diabetes mellitus and osteoporosis from large volumes of data. "Big Data" techniques involving supervised machine lea...
OBJECTIVES: Risk adjustment algorithms for ICU mortality are necessary for measuring and improving ICU performance. Existing risk adjustment algorithms are not widely adopted. Key barriers to adoption include licensing and implementation costs as wel...
This study explored the use of unsupervised machine learning to identify subgroups of patients with heart failure who used telehealth services in the home health setting, and examined intercluster differences for patient characteristics related to me...
OBJECTIVE: The aim of this work is to improve the state of the art for motor-control with a brain-machine interface (BMI). BMIs use neurological recording devices and decoding algorithms to transform brain activity directly into real-time control of ...
MOTIVATION: Recent high-throughput sequencing advances have expanded the breadth of available omics datasets and the integrated analysis of multiple datasets obtained on the same samples has allowed to gain important insights in a wide range of appli...
Journal of X-ray science and technology
Jan 1, 2018
Statistical noise may degrade the x-ray image quality of digital radiography (DR) system. This corruption can be alleviated by extending exposure time of detectors and increasing the intensity of radiation. However, in some instances, such as the sec...
Studies in health technology and informatics
Jan 1, 2018
We report on the development and evaluation of a prototype tool aimed to assist laymen/patients in understanding the content of clinical narratives. The tool relies largely on unsupervised machine learning applied to two large corpora of unlabeled te...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2018
Electronic Health Records (EHRs) contain a wealth of patient data useful to biomedical researchers. At present, both the extraction of data and methods for analyses are frequently designed to work with a single snapshot of a patient's record. Health ...