AIMC Topic: Viral Nonstructural Proteins
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Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations.
Proceedings of the National Academy of Sciences of the United States of America
Dec 26, 2018
Biophysical interactions between proteins and peptides are key determinants of molecular recognition specificity landscapes. However, an understanding of how molecular structure and residue-level energetics at protein-peptide interfaces shape these l...
Smartphone-based fluorescent lateral flow immunoassay platform for highly sensitive point-of-care detection of Zika virus nonstructural protein 1.
Analytica chimica acta
Dec 23, 2018
Simple, inexpensive, and rapid diagnostic tests in low-resource settings with limited laboratory equipment and technical expertise are instrumental in reducing morbidity and mortality from epidemic infectious diseases. We developed a smartphone-based...
HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer.
Breast cancer (Tokyo, Japan)
Dec 28, 2017
BACKGROUND: Hepatitis C virus (HCV) has the lymphotropic feature that is supposed to be the reason of related extrahepatic manifestation. HCV viral oncoproteins may participate in the regulation of some gene expression that has been implicated in tum...
Hepatitis C Antibodies
Gene Expression Regulation, Neoplastic
Enzyme-Linked Immunosorbent Assay
Humans
Adult
Female
Hepacivirus
Carcinogenesis
Neoplasm Staging
Breast Neoplasms
Egypt
Aged
Middle Aged
Hepatitis C
Neoplasm Grading
Viral Nonstructural Proteins
Disease Progression
Fibronectins
Mucin-1
Incidence
QSAR studies of the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by multiple linear regression (MLR) and support vector machine (SVM).
Bioorganic & medicinal chemistry letters
May 3, 2017
In this study, quantitative structure-activity relationship (QSAR) models using various descriptor sets and training/test set selection methods were explored to predict the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by using a ...
Drug repurposing targeting COVID-19 3CL protease using molecular docking and machine learning regression approaches.
Scientific reports
May 28, 2025
The COVID-19 pandemic has initiated a global health emergency, with an exigent need for an effective cure. Progressively, drug repurposing is emerging as a promising solution for saving time, cost, and labor. However, the number of drug candidates th...
Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods.
Journal of medical virology
Feb 1, 2025
Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct-acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan-genotypic DAAs are unavailable, a...
Mutation prediction in the SARS-CoV-2 genome using attention-based neural machine translation.
Mathematical biosciences and engineering : MBE
May 20, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has been evolving rapidly after causing havoc worldwide in 2020. Since then, it has been very hard to contain the virus owing to its frequently mutating nature. Changes in its genome lead t...
Optimal Scree-CNN for Detecting NS1 Molecular Fingerprint from Salivary SERS Spectra.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
Dengue fever (DF) is a viral infection with possible fatal consequence. NS1 is a recent antigen based biomarker for dengue fever (DF), as an alternative to current serum and antibody based biomarkers. Convolutional Neural Network (CNN) has demonstrat...
Prokaryotic Expression of Hepatitis C Virus-NS3 Protein and Preparation of a Monoclonal Antibody.
Monoclonal antibodies in immunodiagnosis and immunotherapy
Dec 1, 2017
Hepatitis C virus (HCV) is a significant health threat that has been extensively investigated worldwide. Improving the sensitivity and specificity of laboratory tests for screening and early diagnosis of HCV in a relevant population is an effective m...
Model Selection for PCA-Linear SVM for automated detection of NS1 molecule from Raman spectra of salivary mixture.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Aug 1, 2015
Of recent, detection of Non-structural Protein 1 (NS1) in saliva has become appealing, as it may lead to a noninvasive detection method for NS1-related diseases at the febrile phase, before complication developed. NS1 is found to have a molecular fin...
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