Protein aggregation is a pathological hallmark of more than 50 human diseases and a major problem for biotechnology. Methods have been proposed to predict aggregation from sequence, but these have been trained and evaluated on small and biased experi...
Astrocytes regulate synaptic activity across large brain territories via their complex, interconnected morphology. Emerging evidence supports the involvement of astrocytes in shaping relapse to opioid use through morphological rearrangements in the n...
In dexterous robotic hand design, achieving high mobility and adaptability comparable to human hands remains an ongoing challenge. Biomimetic designs mimicking the musculoskeletal structure have shown promise yet face difficulties in preserving key k...
Animal bodies act as physical controllers, with their finely tuned passive mechanical responses physically "encoding" complex movements and environmental interactions. This capability allows animals to perform challenging tasks with minimal muscular ...
Machine learning has advanced unprecedentedly, exemplified by GPT-4 and SORA. However, they cannot parallel human brains in efficiency and adaptability due to differences in signal representation, optimization, runtime reconfigurability, and hardware...
Using millions of methylation segments, we developed DiffuCpG, a generative artificial intelligence (AI) diffusion model designed to solve the critical challenge of missing data in high-throughput methylation technologies. DiffuCpG goes beyond conven...
Wearable robotic devices have become increasingly prevalent in both occupational and rehabilitative settings, yet their widespread adoption remains inhibited by usability barriers related to comfort, restriction, and noticeable functional benefits. A...
Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune function research. Here, we introduce a deep learning framework for single-T cell transcriptome and ...
Vasculature morphology and hierarchy are essential for blood perfusion. Human retinal circulation is an intricate vascular system emerging and remerging at the optic nerve head (ONH). Tracing retinal vascular branching from ONH can allow detailed mor...
Dexterous manipulation remains an aspirational goal for autonomous robotic systems, particularly when learning to lift and rotate objects against gravity with intermittent finger contacts. We use model-free reinforcement learning to compare the effec...