Biological age is an important indicator of organ functions and health. Although mammograms are widely used in breast cancer screening, the potential of mammogram-based biological age predictors remains underexplored. Here, we propose a deep learning...
Urinary stones, one of the most common emergency conditions, traverse the ureter, urine flow is obstructed, resulting in hydronephrosis and severe pain. However, vessel wall calcifications or phleboliths are frequently observed in abdominal and pelvi...
Large language models (LLMs) such as ChatGPT have gained attention for their potential to assist clinical decision-making in oncology. However, real-world validation of these models against multidisciplinary tumor board (MTB) recommendations-particul...
Prognostic stratification of Hodgkin lymphoma (HL) patients in ICU remains challenging, with conventional scoring systems often overlooking pathophysiological biomarkers. This retrospective cohort study analyzed 1,908 HL patients from the MIMIC-IV da...
. sleep staging is essential for diagnosing sleep disorders and managing sleep health. Traditional methods require time-consuming manual scoring. Recent photoplethysmography (PPG)-based deep learning models perform well on local datasets but struggle...
BACKGROUND: Age-associated memory impairment (AAMI) is a predementia state linked to endothelial dysfunction. The endothelial activation and stress index (EASIX) quantifies endothelial injury, yet its association with cognitive function remains unval...
BACKGROUND: Evidence regarding the association between physical activity (PA) and diabetic retinopathy (DR) remains inconsistent. Furthermore, its effects on retinal vessel diameters in type 2 diabetes are not well established. We aimed to investigat...
Progress in neuro-psychopharmacology & biological psychiatry
Dec 4, 2025
PURPOSE: Metabolic disturbances are hallmark pathological features of Parkinson's disease (PD) and can be noninvasively captured by arterial spin labeling (ASL). However, the metabolic pattern of disconnections beyond regional alterations remains sca...
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with serious long-term effects if untreated, emphasizing the need for early treatment given its neurobiological heterogeneity. This study introduces a novel expla...
The interplay between diet and gut microbiome composition is complex. Faecal metabolites, the end products of human and microbial metabolism, provide insights into these interactions. Here, we integrate faecal metabolomics, metagenomics, and habitual...
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