AIMC Topic: Analgesics, Opioid

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Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning.

BMC research notes Jan 27, 2018
OBJECTIVE: Use of opioids for pain management has increased over the past decade; however, inadequate analgesic response is common. Genetic variability may be related to opioid efficacy, but due to the many possible combinations and variables, statis...
Receptors, Opioid, delta Humans Female Morphine Aged Gene Frequency Male Cancer Pain Support Vector Machine Receptors, Opioid, mu Dose-Response Relationship, Drug Catechol O-Methyltransferase Analgesics, Opioid Middle Aged Polymorphism, Single Nucleotide Genotype
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The Cost-Effectiveness of Using PARO, a Therapeutic Robotic Seal, to Reduce Agitation and Medication Use in Dementia: Findings from a Cluster-Randomized Controlled Trial.

Journal of the American Medical Directors Association Jan 9, 2018
OBJECTIVES: To examine the within-trial costs and cost-effectiveness of using PARO, compared with a plush toy and usual care, for reducing agitation and medication use in people with dementia in long-term care.
Humans Cost-Benefit Analysis Female Male Cholinesterase Inhibitors Aged Antipsychotic Agents Dementia Aged, 80 and over Australia Antidepressive Agents Robotics Psychomotor Agitation Analgesics, Opioid Play and Playthings
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The distribution and redistribution of fentanyl & norfentanyl in post mortem samples.

Forensic science international Dec 28, 2017
This article compares 249 post mortem case reports that were positive for fentanyl/norfentanyl. All the cases were submitted to, and analyzed by, the toxicology department of the Office of the Chief Medical Examiner, Edmonton, Alberta, Canada. This s...
Forensic Toxicology Tandem Mass Spectrometry Vitreous Body Opioid-Related Disorders Humans Accidents Liver Postmortem Changes Chromatography, Liquid Drug Overdose Analgesics, Opioid Fentanyl
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[Subcostal transversus abdominis plane block can improve analgesia after laparoscopic cholecystectomy].

Brazilian journal of anesthesiology (Elsevier) Dec 23, 2017
BACKGROUND AND GOAL OF STUDY: After laparoscopic cholecystectomy, patients have moderate pain in the early postoperative period. Some studies shown beneficial effects of subcostal transversus abdominis plane block on reducing this pain. Our goal was ...
Male Middle Aged Adolescent Nerve Block Pain Measurement Cholecystectomy, Laparoscopic Analgesia Abdominal Muscles Pain, Postoperative Analgesics, Opioid Prospective Studies Female Aged Young Adult Adult Humans
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Preoperative cesarean delivery intravenous acetaminophen treatment for postoperative pain control: a randomized double-blinded placebo control trial.

American journal of obstetrics and gynecology Dec 21, 2017
BACKGROUND: The United States currently has an opioid use disorder epidemic and research evaluating ways to minimize the use of opioids postsurgery are needed. One of these options is intravenous acetaminophen. If the use of preoperative intravenous ...
Fetal Blood Humans Acetaminophen Prospective Studies Pregnancy Analgesics, Non-Narcotic Female Pain Measurement Preoperative Care Double-Blind Method Cesarean Section Pain, Postoperative Young Adult Analgesics, Opioid Adult Administration, Intravenous Length of Stay
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Communication with Orthopedic Trauma Patients via an Automated Mobile Phone Messaging Robot.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association Dec 20, 2017
BACKGROUND: Communication with orthopedic trauma patients is traditionally problematic with low response rates (RRs). The purpose of this investigation was to (1) evaluate the feasibility of communicating with orthopedic trauma patients postoperative...
Humans Prospective Studies Female Adult Male United States Musculoskeletal System Pain Management Wounds and Injuries Robotics Text Messaging Pain Measurement Orthopedics Pain, Postoperative Trauma Centers Feasibility Studies Analgesics, Opioid
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A randomized comparison between interscalene and combined infraclavicular-suprascapular blocks for arthroscopic shoulder surgery.

Canadian journal of anaesthesia = Journal canadien d'anesthesie Dec 19, 2017
BACKGROUND: This randomized trial aimed to evaluate combined infraclavicular-suprascapular blocks (ICB-SSBs) as a diaphragm-sparing alternative to interscalene blocks (ISBs) for arthroscopic shoulder surgery. We hypothesized that ICB-SSB would provid...
Brachial Plexus Block Epinephrine Levobupivacaine Shoulder Joint Humans Anesthetics, Local Female Analgesics, Opioid Ultrasonography, Interventional Aged Morphine Pain, Postoperative Adult Arthroscopy Male Middle Aged
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Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request.

Journal of biomedical semantics Mar 3, 2017
BACKGROUND: The Drug Ontology (DrOn) is an OWL2-based representation of drug products and their ingredients, mechanisms of action, strengths, and dose forms. We originally created DrOn for use cases in comparative effectiveness research, primarily to...
Humans Software Antihypertensive Agents Drug Monitoring Analgesics, Opioid Antimalarials Data Mining Biological Ontologies
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Effectiveness of continuous wound infusion of local anesthetics after abdominal surgeries.

The Journal of surgical research Dec 29, 2016
BACKGROUND: To assess the effectiveness of continuous preperitoneal wound infusion of local anesthetic drug bupivacaine in providing pain relief, reducing opioid consumption, and enhancing postoperative recovery.
Humans Infusions, Parenteral Treatment Outcome Infusions, Intralesional Follow-Up Studies Adult Anesthetics, Local Male Pain Measurement Middle Aged Double-Blind Method Pain, Postoperative Adolescent Morphine Prospective Studies Drug Therapy, Combination Bupivacaine Female Abdomen Drug Administration Schedule Analgesics, Opioid Aged Aged, 80 and over Young Adult
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Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.

Journal of clinical anesthesia Dec 22, 2016
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays function...
Nausea Analgesia, Epidural Osteoarthritis Analgesia, Patient-Controlled Arthroplasty, Replacement, Knee Pain Management Patient Satisfaction Amides Postoperative Care Anesthetics, Local Pain Measurement Double-Blind Method Aged Pain, Postoperative Male Bupivacaine Middle Aged Ropivacaine Treatment Outcome Humans Analgesics, Opioid Drug Combinations Fentanyl Prospective Studies Female
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