Chironomids of the genus Shilovia Makarchenko (Diamesinae, Boreoheptagyiini) from the mountains of Central Asia are revised using both morphological characters and molecular data. Illustrated descriptions of the adult male Shilovia xinhuawangi sp. no...
Many biological applications require the segmentation of cell bodies, membranes and nuclei from microscopy images. Deep learning has enabled great progress on this problem, but current methods are specialized for images that have large training datas...
Proceedings of the National Academy of Sciences of the United States of America
Dec 14, 2020
Microscopic evaluation of resected tissue plays a central role in the surgical management of cancer. Because optical microscopes have a limited depth-of-field (DOF), resected tissue is either frozen or preserved with chemical fixatives, sliced into t...
Permeation through the blood-brain barrier (BBB) is among the most important processes controlling the pharmacokinetic properties of drugs and other bioactive compounds. Using the fragmental (substructural) descriptors representing the occurrence num...
Movement ecology has traditionally focused on the movements of animals over large time scales, but, with advancements in sensor technology, the focus can become increasingly fine scale. Accelerometers are commonly applied to quantify animal behaviour...
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Animal : an international journal of animal bioscience
Dec 10, 2020
Stretching behavior is one of the broiler comfort behaviors that could be used for animal welfare assessment. However, there is currently no methodology for automatic monitoring of stretching behavior under representative production practices. The ob...
The constant evolution of the illicit drug market makes the identification of unknown compounds problematic. Obtaining certified reference materials for a broad array of new analogues can be difficult and cost prohibitive. Machine learning provides a...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dec 9, 2020
In the era of big data, massive genetic data, as a new industry, has quickly swept almost all industries, especially the pharmaceutical industry. As countries around the world start to build their own gene banks, scientists study the data to explore ...
The hypothesis that destructive mass extinctions enable creative evolutionary radiations (creative destruction) is central to classic concepts of macroevolution. However, the relative impacts of extinction and radiation on the co-occurrence of specie...
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