AIMC Topic: Animals

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Nuclear receptors in metabolic, inflammatory, and oncologic diseases: mechanisms, therapeutic advances, and future directions.

European journal of medical research
Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that regulate gene expression in response to metabolic, hormonal, and environmental signals. These receptors play a critical role in metabolic homeostasis, inflammati...

From mazes to automation: Modernizing working memory research in animal models.

Behavioural brain research
Working memory (WM) is a core cognitive mechanism necessary for adaptive behavior. In the last few decades, scientists have studied WM using rodent models through traditional and time-consuming approaches, such as the Radial Arm Maze and the T-Maze. ...

Separation, characterization, AI screening, and bioactivities of marine bioactive peptides: A review.

Food chemistry
Marine bioactive peptides (MBPs) are short-chain amino acid polymers derived from marine sources that possess specific physiological activities. Owing to their unique origins and structural diversity, MBPs have attracted considerable research interes...

De-MSI: A Deep Learning-Based Data Denoising Method to Enhance Mass Spectrometry Imaging by Leveraging the Chemical Prior Knowledge.

Analytical chemistry
Mass spectrometry imaging (MSI) is a label-free technique that enables the visualization of the spatial distribution of thousands of ions within biosamples. Data denoising is the computational strategy aimed at enhancing the MSI data quality, providi...

Hollow polydopamine for the enhanced ultrasensitive dual-modal immunochromatographic detection of Salmonella typhimurium in dairy products via machine learning.

Mikrochimica acta
Salmonella typhimurium (S. typhimurium) A dual-mode colorimetric/photothermal immunochromatographic strip (ICS) employing hollow polydopamine nanoparticles (h-PDA) is reported for the ultrasensitive detection of Salmonella typhimurium (S. typhimurium...

Mechanisms responsible for the ability of enoxaparin sodium to inhibit inflammatory responses in the immune microenvironment of bone repair: A transcriptomic sequencing study.

PloS one
Enoxaparin sodium (ES), a low molecular weight heparin derivative, has recently been recognized for its diverse biological activities. In particular, the ability of heparin to modulate inflammation has been utilized to enhance the biocompatibility of...

Curcumenol exerts anti-pulmonary fibrosis effects through modulation of the immune signature target SPP1: based on comprehensive bioinformatics and experiments validation.

International immunopharmacology
BACKGROUND: The efficacy of Curcuma wenyujin (C. wenyujin) volatile oil components in the treatment of lung diseases, including pulmonary fibrosis (PF), is gradually being recognized. However, the anti-PF potential and underlying mechanisms of curcum...

Bone marrow immune remodeling in depression: TNF/NF-κB mediated leukocyte redistribution and construction of an interpretable predictive model.

International immunopharmacology
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse mode...

Advances and Outlook of Tea Polyphenol Chemistry: A Review.

Journal of agricultural and food chemistry
Tea is one of the most widely consumed beverages globally, whereas tea polyphenols are always receiving the most attention in scientific research. In past decades, the polyphenols, their derivatives, and oligomers and polymers which possess potential...