The C. elegans ventral nerve cord (VNC) provides a genetically tractable model for investigating the developmental mechanisms involved in neuronal positioning and organization. The VNC of newly hatched larvae contains a set of 22 motoneurons organize...
Population movements constitute a significant driver of cultural change in prehistoric societies. In recent years, sulfur isotopes have emerged as a valuable approach for distinguishing human/animal provenance. However, the scarcity of sulfur isotope...
PGE2 plays important roles in immune cell function and in potentiating tissue regeneration. 15-PGDH is the key enzyme involved in inactivation of PGE2 and its inhibition therefore provides valuable therapeutic opportunity. We have solved the first co...
BACKGROUND: Depression is a prevalent mental disorder, and prolonged exposure to social defeat is a major contributing factor in the onset of depression. Repeated social defeat stress (RSDS) is a commonly used animal model for depression, significant...
Metaviromic studies of potential emerging infection reservoirs led to discovery of many novel viruses. Since metaviromes contain viruses from target host, its food or other sources, fast and robust approaches are needed to predict hosts of unknown vi...
Melt electro-writing (MEW) is an advanced 3D printing technique with significant potential in tissue engineering due to its ability to create highly precise microscale structures using biocompatible materials. This review provides a comprehensive gui...
Systems biology in reproductive medicine
Aug 26, 2025
Early embryo development and competence mechanisms are paramount to ART's success but are still underexplored in human-relevant animal models. Clinical embryo evaluation remains largely based on subjectively evaluated morphological characteristics. I...
Journal of controlled release : official journal of the Controlled Release Society
Aug 25, 2025
The clinical translation of DDS is still one of the most challenging issues for the further development of therapeutic breakthroughs, especially for cancer and complex diseases. This review provides a critical overview of the factors that influence t...
Autoimmune diseases are driven by dysregulated cytokine networks, where excessive cytokines such as TNF-α, IL-6, IL-17, and IL-23 promote chronic inflammation and tissue damage. While monoclonal antibodies effectively neutralise these cytokines, they...
Stem cell therapy is a prospective approach to the treatment of spinal cord injury (SCI), which features grievous harm of motor and sensory functions. However, the proportion of motor neurons spontaneously differentiated from neural stem cells (NSCs)...
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