Protein aggregation is one of the key challenges in the biopharmaceutical industry as its control is crucial in achieving long-term stability and efficacy of biopharmaceuticals. Attempts have been made to develop regression models for predicting the ...
Antibodies are versatile therapeutic molecules that use combinatorial sequence diversity to cover a vast fitness landscape. Designing optimal antibody sequences, however, remains a major challenge. Recent advances in deep learning provide opportuniti...
The impact of various charge mutations on the second osmotic virial coefficient was examined for three model therapeutic monoclonal antibodies (MAbs) at representative formulation pH values by using coarse-grained (CG) molecular modeling. The wild-ty...
Cephalalgia : an international journal of headache
Jun 12, 2025
BackgroundUnderstanding characteristics and reasons associated with using calcitonin gene-related peptide monoclonal antibodies (CGRP mAb) for migraine prevention may help clinicians individualize treatment plans and achieve better patient outcomes.M...
Developing therapeutic antibodies is a challenging endeavor, often requiring large-scale screening to produce initial binders, that still often require optimization for developability. We present a computational pipeline for the discovery and design ...
OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease. Chest high-resolution CT (HRCT) is instrumental in IPF management, and the Quantitative Lung Fibrosis (QLF) score is a computer-assisted metric for quantifyin...
Journal of chemical information and modeling
Apr 11, 2025
The pharmaceutical industry faces challenges in developing efficient and cost-effective drug delivery systems. Among various applications, antibody-drug conjugates (ADCs) stand out by combining cytotoxic or bioactive agents with monoclonal antibodies...
Antibody discovery has been successful in designing and progressing molecules to the clinic and market based on largely empirical methods and human experience. The field is now transitioning from classical monospecific antibodies to innovative smart ...
Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application o...
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