AIMC Topic: Apoptosis
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Mechanism of TNF- α inducing apoptosis and autophagy of chondrocytes by activating NF- κ B signal pathway.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2023
This study aimed to explore the mechanism of apoptosis and autophagy of chondrocytes induced by tumor necrosis factor α (TNA-α) by activating the NF-κB signal pathway. For this purpose, 24 SD rats were selected for feeding. The knee cartilage was cut...
Influences of microRNA-451 on the expression of HMGB1 in myocardial cells and its mechanism in ischemia-reperfusion injury.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2023
This work aimed to understand the underlying mechanism of micro-ribonucleic acid (MicroRNA) (miR)-451 in ischemia-reperfusion injury (IRI) and the influences of miR-451 on high mobility group box 1 protein (HMGB1) in myocardial cells, 30 specific pat...
Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 31, 2023
The objective of this study was to investigate the improvement effect of Astragalus (AS) extract on oxidative stress (OS) and inflammatory response of myocarditis (MYO) cells through the STAT3/IL-6 axis. For this purpose, The MYO model cells prepared...
Postbiotic Activities of : Impacts on Viability, Structural Integrity, and Cell Death Markers in Human Intestinal C2BBe1 Cells.
Pathogens (Basel, Switzerland)
Dec 23, 2023
Acute diarrheal disease (ADD) caused by rotavirus (RV) contributes significantly to morbidity and mortality in children under five years of age. Currently, there are no specific drugs for the treatment of RV infections. Previously, we reported the an...
Effects of targeting highly expressed in cancer protein 1 (Hec1) inhibitor INH 1 in breast cancer cell lines In Vitro.
Cellular and molecular biology (Noisy-le-Grand, France)
Dec 20, 2023
In the present study, the in vitro antiproliferative effect of targeting highly expressed cancer protein 1 (Hec1) inhibitor INH1 was investigated in estrogen receptor-positive MCF-7 cell line originating from an in situ carcinoma and triple negative ...
Prediction of Spheroid Cell Death Using Fluorescence Staining and Convolutional Neural Networks.
Chemical research in toxicology
Dec 5, 2023
Three-dimensional (3D) cell culture is emerging for drug design and drug screening. Skin toxicity is one of the most important assays for determining the toxicity of a compound before being used in skin application. Much work has been done to find an...
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Acta pharmacologica Sinica
Oct 6, 2023
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers in the world. The therapeutic outlook for HCC patients has significantly improved with the advent and development of systematic and targeted therapies such as sorafenib and l...
Comprehensive scientometrics and visualization study profiles lymphoma metabolism and identifies its significant research signatures.
Frontiers in endocrinology
Sep 26, 2023
BACKGROUND: There is a wealth of poorly utilized unstructured data on lymphoma metabolism, and scientometrics and visualization study could serve as a robust tool to address this issue. Hence, it was implemented.
β-D-Glucan promotes NF-κB activation and ameliorates high-LET carbon-ion irradiation-induced human umbilical vein endothelial cell injury.
Turkish journal of medical sciences
Sep 21, 2023
BACKGROUND/AIM: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is ...
Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning.
Hereditas
Aug 24, 2023
BACKGROUND: Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. Nonetheless, the accurate diagnosis of this condition continues to pose a challenge when relying on conventional diagnostic techniques. Cell death is a key factor in ...
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