Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, and personalized precision medicine, yet current approaches focusing mainly on circulating host cell-free DNA (cfDNA) neglect crucial information withi...
BACKGROUND: Renal cell carcinoma (RCC), which accounts for 70-90% of kidney malignancies, remains difficult to diagnose early due to its asymptomatic onset and the lack of reliable biomarkers. This study aimed to develop a robust diagnostic model by ...
Gastric cancer (GC) is a leading cause of cancer-related mortality globally. Histone lactylation, an emerging post-translational modification, holds promise as a therapeutic target and prognostic biomarker, though its expression patterns and clinical...
Rapid, accurate, and renewable electrochemiluminescence (ECL) bioassays are crucial for multiplexed biomarker detection. Integrated with efficient analytical model for processing sensing data, these tools enable precise differentiation of tumor stage...
Prostate cancer (PCa) remains a leading cause of cancer-related mortality in men, with challenges in diagnosis and treatment due to tumor heterogeneity. This study identifies palmitoylation-related signature genes as potential diagnostic and therapeu...
Early detection of lung adenocarcinoma (LUAD) remains a major clinical challenge despite the widespread application of low-dose computed tomography (LDCT). Circulating PIWI-interacting RNAs (piRNAs), characterized by tumor-specific expression and hig...
Chimeric antigen receptor (CAR) T-cell therapy has shown significant success in treating diffuse large B-cell lymphoma (DLBCL). The initial step involves collecting autologous CD3 lymphocytes through apheresis, in which obtaining an adequate CD3 cell...
Primary vitreoretinal lymphoma (PVRL) is a rare and aggressive intraocular malignancy that is frequently misdiagnosed because of its nonspecific early manifestations and the lack of effective screening tools. We conduct a multicentre case-control stu...
The adoption of whole genome sequencing (WGS) in clinical oncology is challenged by low data quality and increased artifacts in standard-of-care formalin-fixed paraffin-embedded (FFPE) samples. Analysis of 56 fresh frozen (FF) and FFPE matched pairs ...
Meningioma, the most prevalent primary intracranial tumor, presents significant clinical challenges due to unclear molecular mechanisms underlying its progression from low-grade (LG) to high-grade (HG) and lack of grade-specific biomarkers. Here, we ...
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