BACKGROUND: While the Cardiometabolic Index (CMI) serves as a novel marker for assessing adipose tissue distribution and metabolic function, its prognostic utility for cardiovascular disease (CVD) events remains incompletely understood. This investig...
Fungal pathogens significantly impact human health, agriculture, and ecosystems, with infections leading to high morbidity and mortality, especially among immunocompromised individuals. The increasing prevalence of antifungal resistance (AFR) exacerb...
Integrating and analyzing multiple omics datasets, such as genomics, environmental influences, and imaging endophenotypes, has yielded an abundance of candidate biomarkers. However, translating such findings into beneficial clinical knowledge for dis...
International journal of molecular sciences
40244055
Neutrophil extracellular traps (NETs) play a key role in the development of bronchopulmonary dysplasia (BPD), yet their molecular mechanisms in contributing to BPD remain unexplored. Using the GSE32472 dataset, which includes 100 blood samples from p...
PURPOSE: To identify biomarkers for diagnosis and classification of interstitial cystitis/bladder pain syndrome (IC/BPS) by urinary lipidomics coupled with machine learning.
BACKGROUND: Severe esophagogastric varices (EGVs) significantly affect prognosis of patients with hepatitis B because of the risk of life-threatening hemorrhage. Endoscopy is the gold standard for EGV detection but it is invasive, costly and carries ...
BACKGROUND: The American Heart Association recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome, highlighting the increasing importance of the complex interplay between metabolic, renal, and cardiovascular diseases (CVD)....
BACKGROUND: Parkinson's disease (PD), a prevalent neurodegenerative disorder in the aging population, poses significant challenges in unraveling its pathogenesis and progression. A key area of investigation is the disruption of oncological metabolic ...
Ischemic cerebral infarction is the most prevalent type of stroke, causing significant disability and death worldwide. Transient ischemic attack (TIA) is a strong predictor of subsequent stroke. Individuals with dysmetabolism, such as hypertension, h...
Computer methods and programs in biomedicine
40239454
BACKGROUND: Osteoarthritis (OA) is a common degenerative joint disease, particularly affecting individuals aged >50 years. It deteriorates quality of life and restricts physical activity in the elderly. Early diagnosis of OA is crucial for effective ...