AIMC Topic: Blood Chemical Analysis

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A sensitive and rapid UFLC-APCI-MS/MS bioanalytical method for quantification of endogenous and exogenous Vitamin K1 isomers in human plasma: Development, validation and first application to a pharmacokinetic study.

Talanta
Due to lack of suitable bioanalytical methods in previous literature, for simultaneous estimation of Vitamin K1 isomers, in compliance with the current regulatory expectation, we aimed to develop a sensitive and rapid method with UFLC-APCI-MS/MS (ult...

Integration of metabolomics, lipidomics and clinical data using a machine learning method.

BMC bioinformatics
BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Ce...

Evaluation of supervised machine-learning algorithms to distinguish between inflammatory bowel disease and alimentary lymphoma in cats.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Inflammatory bowel disease (IBD) and alimentary lymphoma (ALA) are common gastrointestinal diseases in cats. The very similar clinical signs and histopathologic features of these diseases make the distinction between them diagnostically challenging. ...

Automated, high-throughput serum glycoprofiling platform.

Integrative biology : quantitative biosciences from nano to macro
Complex carbohydrates are rapidly becoming excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of clinical glycobiomarkers has been slow, due to the scarcity of high-throughput glycoanalyti...

An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum.

Analytical and bioanalytical chemistry
An automated high-throughput solid phase extraction (SPE) micro-elution method for 8 perfluorosulfonic acids, 11 perfluorocarboxylic acids and fluorooctane sulfonamide in human serum was developed. Importance was attached to the application of small ...

Noninvasive blood glucose sensing using near infra-red spectroscopy and artificial neural networks based on inverse delayed function model of neuron.

Journal of medical systems
In this paper, a non-invasive blood glucose sensing system is presented using near infra-red(NIR) spectroscopy. The signal from the NIR optodes is processed using artificial neural networks (ANN) to estimate the glucose level in blood. In order to ob...

Investigating handheld near-infrared spectroscopy for forensic body fluid analysis.

Science & justice : journal of the Forensic Science Society
Forensic casework and crime scene examination will often involve the identification and analysis of biological evidence found on a wide variety of surfaces. One type of biological evidence most commonly encountered at the crime scene is body fluids, ...