AIMC Topic: Blood Proteins
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A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients' cells and serum.
Scientific reports
Jul 1, 2025
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Identification of plasma proteins associated with seizures in epilepsy: A consensus machine learning approach.
PloS one
Jul 1, 2025
Blood-based biomarkers in epilepsy could constitute important research tools advancing neurobiological understanding and valuable clinical tools for better diagnosis and follow-up. An interesting question is whether biomarker patterns could contribut...
A correlational study of plasma galectin-3 as a potential predictive marker of postoperative delirium in patients with acute aortic dissection.
Scientific reports
May 8, 2025
This study aimed to demonstrate whether plasma galectin-3 could predict the development of postoperative delirium (POD) in patients with acute aortic dissection (AAD). Prospective, observational study. Cardiac surgery intensive care unit. Consecutive...
Machine learning approach on plasma proteomics identifies signatures associated with obesity in the KORA FF4 cohort.
Diabetes, obesity & metabolism
Feb 27, 2025
AIMS: This study investigated the role of plasma proteins in obesity to identify predictive biomarkers and explore underlying biological mechanisms.
Quantitative abnormalities in the β-region of the electrophoretic profile of serum proteins as predictive markers of monoclonality: Machine learning for monoclonality prediction.
Clinical biochemistry
Feb 1, 2025
OBJECTIVE OF THE STUDY: To develop a machine learning algorithm aimed at predicting the presence of a monoclonal (M-) protein when the β-globulin fraction is elevated.
Machine learning models for predicting interaction affinity energy between human serum proteins and hemodialysis membrane materials.
Scientific reports
Jan 28, 2025
Membrane incompatibility poses significant health risks, including severe complications and potential fatality. Surface modification of membranes has emerged as a pivotal technology in the membrane industry, aiming to improve the hemocompatibility an...
Performance and efficiency of machine learning models in analyzing capillary serum protein electrophoresis.
Clinica chimica acta; international journal of clinical chemistry
Jan 26, 2025
BACKGROUND AND OBJECTIVE: Serum protein electrophoresis (SPEP) plays a critical role in diagnosing diseases associated with M-proteins. However, its clinical application is limited by a heavy reliance on experienced experts.
MAGPIE: A Machine Learning Approach to Decipher Protein-Protein Interactions in Human Plasma.
Journal of proteome research
Jan 7, 2025
Immunoprecipitation coupled to tandem mass spectrometry (IP-MS/MS) methods are often used to identify protein-protein interactions (PPIs). While these approaches are prone to false positive identifications through contamination and antibody nonspecif...
A Plasma Proteomics-Based Model for Identifying the Risk of Postpartum Depression Using Machine Learning.
Journal of proteome research
Jan 7, 2025
Postpartum depression (PPD) poses significant risks to maternal and infant health, yet proteomic analyses of PPD-risk women remain limited. This study analyzed plasma samples from 30 healthy postpartum women and 30 PPD-risk women using mass spectrome...
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