Distinguishing osteosarcoma from bone callus remains a clinical challenge due to their morphological similarities. This study proposes J-CAN, a multimodal deep learning framework integrating hyperspectral imaging (HSI) and H&E-stained pathology for r...
Computer methods and programs in biomedicine
Jun 1, 2025
BACKGROUND AND OBJECTIVE: Patients with metastatic bone disease are at risk of pathological femoral fractures and may require prophylactic surgical fixation. Current clinical decision support tools often overestimate fracture risk, leading to overtre...
In a rapidly evolving healthcare environment, artificial intelligence (AI) is transforming diagnostic techniques and personalized medicine. This is also seen in osseous biopsies. AI applications in radiomics, histopathology, predictive modelling, bio...
SAPHO syndrome is an inflammatory disorder with bone and cutaneous manifestations, for which whole-body bone scintigraphy (WBBS) is frequently used in diagnosis. The WBBS findings of SAPHO syndromes and secondary bone tumors (SBT) have overlapping fe...
Osteosarcoma, an aggressive bone malignancy predominantly affecting children and adolescents, is characterized by a poor prognosis and high mortality rates. The development of reliable prognostic tools is critical for advancing personalized treatment...
Manual interpretation of CT images for bone metastasis (BM) detection in primary cancer remains challenging. We present an automated Bone Lesion Detection System (BLDS) developed using CT scans from 2518 patients (9177 BMs; 12,824 non-BM lesions) acr...
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...
INTRODUCTION: Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone...
PURPOSE: Bone metastasis is a critical complication in prostate cancer, significantly impacting patient prognosis and quality of life. This study aims to enhance bone metastasis prediction using machine learning (ML) techniques by integrating dynamic...
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
May 1, 2025
OBJECTIVE: The objective of this study was to analyze the incidence and overall survival (OS) of osteosarcoma (OSC) and Ewing's sarcoma (EWS) in a pediatric and adolescent population, employing machine learning (ML) and deep learning (DL) models to p...
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