AIMC Topic: Breast Neoplasms

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Comparative machine learning analysis for predicting organ tropism in breast cancer and identifying key gene signatures.

Computers in biology and medicine
BACKGROUND: Breast cancer metastasis (BCM) metastasizes preferentially to certain organs. Important genetic markers can be used for early detection and treatment. Machine learning (ML) can efficiently handle gene expression data to enhance metastasis...

Biomarker discovery for early breast cancer diagnosis using machine learning on transcriptomic data for biosensor development.

Computers in biology and medicine
Breast cancer is the second leading cause of female mortality globally. Effective diagnostic tools, such as biosensors that utilize reliable biomarkers, are essential for early detection, particularly in low-income countries. This study introduces a ...

Attention-based multimodal deep learning for interpretable and generalizable prediction of pathological complete response in breast cancer.

Journal of translational medicine
BACKGROUND: Accurate prediction of pathological complete response (pCR) to neoadjuvant chemotherapy has significant clinical utility in the management of breast cancer treatment. Although multimodal deep learning models have shown promise for predict...

Machine learning analysis of survival outcomes in breast cancer patients treated with chemotherapy, hormone therapy, surgery, and radiotherapy.

Scientific reports
Breast cancer continues to be a leading cause of death among women in the world. The prediction of survival outcomes based on treatment modalities, i.e., chemotherapy, hormone therapy, surgery, and radiation therapy is an essential step towards perso...

Recurrence prediction of invasive ductal carcinoma from preoperative contrast-enhanced computed tomography using deep convolutional neural network.

Biomedical physics & engineering express
Predicting the risk of breast cancer recurrence is crucial for guiding therapeutic strategies, including enhanced surveillance and the consideration of additional treatment after surgery. In this study, we developed a deep convolutional neural networ...

BIScreener: enhancing breast cancer ultrasound diagnosis through integrated deep learning with interpretability.

Analytical methods : advancing methods and applications
Breast cancer is the leading cause of death among women worldwide, and early detection through the standardized BI-RADS framework helps physicians assess the risk of malignancy and guide appropriate diagnostic and treatment decisions. In this study, ...

Predicting the sonication energy for focused ultrasound surgery treatment of breast fibroadenomas using machine learning algorithms.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
PURPOSE: To establish a predictive model for the sonication energy required for focused ultrasound surgery (FUS) of breast fibroadenomas.

A hybrid deep learning model EfficientNet with GRU for breast cancer detection from histopathology images.

Scientific reports
Breast cancer remains a significant global health challenge among women, with histopathological image analysis playing a critical role in early detection. However, existing diagnostic models often struggle to extract complex patterns from high-resolu...

Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells.

Functional & integrative genomics
The role of epitranscriptomic changes in the development of acquired endocrine therapy (ET)- resistance in estrogen receptor α (ER) expressing breast cancer (BC) is unknown. We tested the hypothesis that inhibition of METTL3, the methyltransferase re...

Integrative multimodal ultrasound and radiomics for early prediction of neoadjuvant therapy response in breast cancer: a clinical study.

BMC cancer
PURPOSE: This study aimed to develop an early predictive model for neoadjuvant therapy (NAT) response in breast cancer by integrating multimodal ultrasound (conventional B-mode, shear-wave elastography, and contrast-enhanced ultrasound) and radiomics...