AIMC Topic: Cell Line
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Artificial intelligence in the early stages of drug discovery.
Archives of biochemistry and biophysics
Dec 19, 2020
Although the use of computational methods within the pharmaceutical industry is well established, there is an urgent need for new approaches that can improve and optimize the pipeline of drug discovery and development. In spite of the fact that there...
Deep Learning Benchmarks on L1000 Gene Expression Data.
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2020
Gene expression data can offer deep, physiological insights beyond the static coding of the genome alone. We believe that realizing this potential requires specialized, high-capacity machine learning methods capable of using underlying biological str...
Simultaneously Detecting Monoamine Oxidase A and B in Disease Cell/Tissue Samples Using Paper-Based Devices.
ACS applied bio materials
Nov 25, 2020
As enzymes in the outer membrane of the mitochondrion, monoamine oxidases (MAOs) can catalyze the oxidative deamination of monoamines in the human body. According to different substrates, MAOs can be divided into MAO-A and MAO-B. The imbalance of the...
Prediction of enhancer-promoter interactions using the cross-cell type information and domain adversarial neural network.
BMC bioinformatics
Nov 7, 2020
BACKGROUND: Enhancer-promoter interactions (EPIs) play key roles in transcriptional regulation and disease progression. Although several computational methods have been developed to predict such interactions, their performances are not satisfactory w...
Weissella cibaria EIR/P2-derived exopolysaccharide: A novel alternative to conventional biomaterials targeting periodontal regeneration.
International journal of biological macromolecules
Oct 22, 2020
Healing and regeneration of periodontium are considered as a complex physiological process. Therefore, treatments need to be addressed with highly effective components modulating the multiple pathways. In this study, exopolysaccharide (EPS) produced ...
Dextrans
Anti-Bacterial Agents
Periodontium
Polysaccharides, Bacterial
Biofilms
Weissella
Microbial Sensitivity Tests
Antioxidants
Chromatography, High Pressure Liquid
Regeneration
Biocompatible Materials
Humans
Spectroscopy, Fourier Transform Infrared
Dose-Response Relationship, Drug
Cell Line
Streptococcus mutans
Spage2vec: Unsupervised representation of localized spatial gene expression signatures.
The FEBS journal
Oct 11, 2020
Investigations of spatial cellular composition of tissue architectures revealed by multiplexed in situ RNA detection often rely on inaccurate cell segmentation or prior biological knowledge from complementary single-cell sequencing experiments. Here,...
Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms.
PLoS computational biology
Sep 24, 2020
Environmental toxicants affect human health in various ways. Of the thousands of chemicals present in the environment, those with adverse effects on the endocrine system are referred to as endocrine-disrupting chemicals (EDCs). Here, we focused on a ...
In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS.
Journal of applied toxicology : JAT
Jul 13, 2020
Electronic nicotine delivery systems (ENDS) are regulated tobacco products and often contain flavor compounds. Given the concern of increased use and the appeal of ENDS by young people, evaluating the potential of flavors to induce DNA damage is impo...
Flavoring Agents
Quantitative Structure-Activity Relationship
Mutagenicity Tests
Histones
Electronic Nicotine Delivery Systems
Consumer Product Safety
Rats
Models, Molecular
Cell Line
DNA Damage
Phosphorylation
Flow Cytometry
Tumor Suppressor Protein p53
Humans
Biomarkers
Machine Learning
Animals
Risk Assessment
Mice
A Coupled FEM-SPH Modeling Technique to Investigate the Contractility of Biohybrid Thin Films.
Advanced biosystems
Jun 9, 2020
Biohybrid actuators have the potential to overcome the limitations of traditional actuators employed in robotics, thanks to the unique features of living contractile muscle cells, which can be used to power artificial elements. This paper describes a...
Intelligent image-based deformation-assisted cell sorting with molecular specificity.
Nature methods
May 25, 2020
Although label-free cell sorting is desirable for providing pristine cells for further analysis or use, current approaches lack molecular specificity and speed. Here, we combine real-time fluorescence and deformability cytometry with sorting based on...
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