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Cerebral Cortex

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Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy.

Human brain mapping
Depression symptom heterogeneity limits the identifiability of treatment-response biomarkers. Whether improvement along dimensions of depressive symptoms relates to separable neural networks remains poorly understood. We build on work describing thre...

The neural representation of abstract words may arise through grounding word meaning in language itself.

Human brain mapping
In order to describe how humans represent meaning in the brain, one must be able to account for not just concrete words but, critically, also abstract words, which lack a physical referent. Hebbian formalism and optimization are basic principles of b...

MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning.

Nature communications
Understanding the basis of brain function requires knowledge of cortical operations over wide spatial scales and the quantitative analysis of brain activity in well-defined brain regions. Matching an anatomical atlas to brain functional data requires...

Single cortical neurons as deep artificial neural networks.

Neuron
Utilizing recent advances in machine learning, we introduce a systematic approach to characterize neurons' input/output (I/O) mapping complexity. Deep neural networks (DNNs) were trained to faithfully replicate the I/O function of various biophysical...

Automatic recognition of specific local cortical folding patterns.

NeuroImage
The study of local cortical folding patterns showed links with psychiatric illnesses as well as cognitive functions. Despite the tools now available to visualize cortical folds in 3D, manually classifying local sulcal patterns is a time-consuming and...

Adaptive Dropout Method Based on Biological Principles.

IEEE transactions on neural networks and learning systems
Dropout is one of the most widely used methods to avoid overfitting neural networks. However, it rigidly and randomly activates neurons according to a fixed probability, which is not consistent with the activation mode of neurons in the human cerebra...

Long-Tailed Characteristic of Spiking Pattern Alternation Induced by Log-Normal Excitatory Synaptic Distribution.

IEEE transactions on neural networks and learning systems
Studies of structural connectivity at the synaptic level show that in synaptic connections of the cerebral cortex, the excitatory postsynaptic potential (EPSP) in most synapses exhibits sub-mV values, while a small number of synapses exhibit large EP...

Deep reasoning neural network analysis to predict language deficits from psychometry-driven DWI connectome of young children with persistent language concerns.

Human brain mapping
This study investigated whether current state-of-the-art deep reasoning network analysis on psychometry-driven diffusion tractography connectome can accurately predict expressive and receptive language scores in a cohort of young children with persis...

Comparative study using inverse ontology cogency and alternatives for concept recognition in the annotated National Library of Medicine database.

Neural networks : the official journal of the International Neural Network Society
This paper introduces inverse ontology cogency, a concept recognition process and distance function that is biologically-inspired and competitive with alternative methods. The paper introduces inverse ontology cogency as a new alternative method. It ...

coupleCoC+: An information-theoretic co-clustering-based transfer learning framework for the integrative analysis of single-cell genomic data.

PLoS computational biology
Technological advances have enabled us to profile multiple molecular layers at unprecedented single-cell resolution and the available datasets from multiple samples or domains are growing. These datasets, including scRNA-seq data, scATAC-seq data and...