AIMC Topic: Clinical Trials as Topic

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Artificial Intelligence (AI) in Rare Diseases: Is the Future Brighter?

Genes Nov 27, 2019
The amount of data collected and managed in (bio)medicine is ever-increasing. Thus, there is a need to rapidly and efficiently collect, analyze, and characterize all this information. Artificial intelligence (AI), with an emphasis on deep learning, h...
Deep Learning Clinical Trials as Topic Rare Diseases Humans Precision Medicine Drug Discovery
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Latent Dirichlet Allocation in predicting clinical trial terminations.

BMC medical informatics and decision making Nov 27, 2019
BACKGROUND: This study used natural language processing (NLP) and machine learning (ML) techniques to identify reliable patterns from within research narrative documents to distinguish studies that complete successfully, from the ones that terminate....
Early Termination of Clinical Trials Narration Natural Language Processing Clinical Trials as Topic Humans Machine Learning Databases, Factual Models, Theoretical
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Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy.

Journal of translational medicine Nov 21, 2019
BACKGROUND: Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospective clinical dataset of Magne...
Humans Machine Learning Algorithms Probability Clinical Trials as Topic International Classification of Diseases Biomarkers Hypoxia-Ischemia, Brain Infant, Newborn Treatment Outcome Magnetic Resonance Imaging
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Predicting translational progress in biomedical research.

PLoS biology Oct 10, 2019
Fundamental scientific advances can take decades to translate into improvements in human health. Shortening this interval would increase the rate at which scientific discoveries lead to successful treatment of human disease. One way to accomplish thi...
Machine Learning Biomedical Research Time Factors Bibliometrics Humans Clinical Trials as Topic Periodicals as Topic Translational Research, Biomedical Practice Guidelines as Topic
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Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score.

Diabetes care Sep 13, 2019
OBJECTIVE: To develop and validate a novel, machine learning-derived model to predict the risk of heart failure (HF) among patients with type 2 diabetes mellitus (T2DM).
Time Factors Diabetes Mellitus, Type 2 Follow-Up Studies Predictive Value of Tests Risk Assessment Incidence Cohort Studies Heart Failure Clinical Trials as Topic Outpatients Female Reproducibility of Results Risk Factors Hospitalization Aged Male Middle Aged Humans Machine Learning
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Multicategory individualized treatment regime using outcome weighted learning.

Biometrics Aug 28, 2019
Individualized treatment regimes (ITRs) aim to recommend treatments based on patient-specific characteristics in order to maximize the expected clinical outcome. Outcome weighted learning approaches have been proposed for this optimization problem wi...
Clinical Trials as Topic Risk Precision Medicine Treatment Outcome Models, Statistical Humans Machine Learning Algorithms Computer Simulation
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A Lightweight API-Based Approach for Building Flexible Clinical NLP Systems.

Journal of healthcare engineering Aug 15, 2019
Natural language processing (NLP) has become essential for secondary use of clinical data. Over the last two decades, many clinical NLP systems were developed in both academia and industry. However, nearly all existing systems are restricted to speci...
Patient Discharge Data Mining Medical Informatics Clinical Trials as Topic False Positive Reactions Reproducibility of Results Humans Obesity Machine Learning Natural Language Processing Databases, Factual Pharmaceutical Preparations
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Machine Learning Approaches for Automated Lesion Detection in Microwave Breast Imaging Clinical Data.

Scientific reports Jul 19, 2019
Breast lesion detection employing state of the art microwave systems provide a safe, non-ionizing technique that can differentiate healthy and non-healthy tissues by exploiting their dielectric properties. In this paper, a microwave apparatus for bre...
Scattering, Radiation Microwave Imaging Breast Breast Neoplasms Neural Networks, Computer ROC Curve Algorithms Support Vector Machine Female Magnetic Resonance Imaging Clinical Trials as Topic Statistics, Nonparametric Dielectric Spectroscopy Humans Mammography Equipment Design Ultrasonography, Mammary
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Artificial Intelligence for Clinical Trial Design.

Trends in pharmacological sciences Jul 17, 2019
Clinical trials consume the latter half of the 10 to 15 year, 1.5-2.0 billion USD, development cycle for bringing a single new drug to market. Hence, a failed trial sinks not only the investment into the trial itself but also the preclinical developm...
Clinical Trials as Topic Drug Development Clinical Trials, Phase III as Topic Humans Patient Selection Clinical Protocols Artificial Intelligence Patient Compliance
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Deep Learning to Assess Long-term Mortality From Chest Radiographs.

JAMA network open Jul 3, 2019
IMPORTANCE: Chest radiography is the most common diagnostic imaging test in medicine and may also provide information about longevity and prognosis.
Humans Neural Networks, Computer Prognosis Female Risk Factors Lung Diseases Middle Aged Aged Clinical Trials as Topic Risk Assessment Male Radiography, Thoracic Deep Learning Cardiovascular Diseases Thorax Mass Screening
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