Biomarkers can offer great promise for improving prevention and treatment of complex diseases such as cancer, cardiovascular diseases, and diabetes. These can be used as either diagnostic or predictive or as prognostic biomarkers. The revolution brou...
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through unsupervised clustering, but the ever increasing number of cells and batch effect impose computational challenges. We present DESC, an unsupervised deep embedding a...
Classifying the images that portray the Human Epithelial cells of type 2 (HEp-2) represents one of the most important steps in the diagnosis procedure of autoimmune diseases. Performing this classification manually represents an extremely complicated...
To analyze types and patterns of greening trends across a city, this study seeks to identify a method of creating very high-resolution urban vegetation maps that scales over space and time. Vegetation poses unique challenges for image segmentation be...
Computer methods and programs in biomedicine
Apr 28, 2020
BACKGROUND AND OBJECTIVE: Identification of subgroups may be useful to understand the clinical characteristics of ICU patients. The purposes of this study were to apply an unsupervised machine learning method to ICU patient data to discover subgroups...
Neural networks : the official journal of the International Neural Network Society
Apr 25, 2020
In this paper, we introduce a neural network framework for semi-supervised clustering with pairwise (must-link or cannot-link) constraints. In contrast to existing approaches, we decompose semi-supervised clustering into two simpler classification ta...
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Apr 13, 2020
Understanding and classifying electromyogram (EMG) signals is of significance for dexterous prosthetic hand control, sign languages, grasp recognition, human-machine interaction, etc.. The existing research of EMG-based hand gesture classification fa...
BACKGROUND: Cancer typically exhibits genotypic and phenotypic heterogeneity, which can have prognostic significance and influence therapy response. Computed Tomography (CT)-based radiomic approaches calculate quantitative features of tumour heteroge...
The global healthcare landscape is continuously changing throughout the world as technology advances, leading to a gradual change in lifestyle. Several diseases such as asthma and cardiovascular conditions are becoming more diffuse, due to a rise in ...
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