BACKGROUND: Sepsis, a life-threatening condition driven by dysregulated host responses to infection, is associated with long-term cognitive impairments resembling Alzheimer's disease (AD). However, the molecular mechanisms linking sepsis-induced cogn...
RATIONALE AND OBJECTIVES: Cognitive decline is common in End-Stage Renal Disease (ESRD) patients, yet its neural mechanisms are poorly understood. This study investigates structural and functional brain network reconfiguration in ESRD patients transi...
OBJECTIVE: Identification of clinically meaningful subphenotypes of disease progression can enhance the understanding of disease heterogeneity and underlying pathophysiology. In this study, we propose a machine learning framework to identify subpheno...
BMC medical informatics and decision making
Apr 1, 2025
BACKGROUND: Cognitive impairment is common after a stroke, but it can often go undetected. In this study, we investigated whether using gait and dual tasks could help detect cognitive impairment after stroke.
Psychiatry and clinical neurosciences
Mar 31, 2025
AIMS: Effective intervention for mild cognitive impairment (MCI) is key for preventing dementia. As a neuroprotective agent, butylphthalide has the potential to treat MCI due to Alzheimer disease (AD). However, the pharmacological mechanism of butylp...
BACKGROUND AND OBJECTIVES: Among the participants of Alzheimer disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals can increase power to detect treatment effects. We...
Alzheimer's disease (AD) is a primary degenerative brain disorder commonly found in the elderly, Mild cognitive impairment (MCI) can be considered a transitional stage from normal aging to Alzheimer's disease. Therefore, distinguishing between normal...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Mar 22, 2025
Alzheimer's disease (AD) poses significant global health challenges due to its increasing prevalence and associated societal costs. Early detection and diagnosis of AD are critical for delaying progression and improving patient outcomes. Traditional ...
BACKGROUND: Cholestasis, characterized by impaired bile flow, impacts cognitive function through systemic mechanisms, including inflammation and metabolic dysregulation. Despite its significance, targeted predictive models for cognitive impairment in...
Detection of Alzheimer's Disease (AD) is critical for successful diagnosis and treatment, involving the common practice of screening for Mild Cognitive Impairment (MCI). However, the progressive nature of AD makes it challenging to identify its causa...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.