AIMC Topic: Colitis, Ulcerative

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Inflammatory bowel disease patients experiencing a loss of response to infliximab regain long-term response after undergoing granulocyte/monocyte apheresis: A case series.

Cytokine Dec 29, 2017
Up to 50% of patients with ulcerative colitis (UC) or Crohn's disease (CD) experience a loss of response (LOR) to infliximab after an initial response to the drug. Granulocyte/monocyte apheresis (GMA) with the Adacolumn depletes the activated myeloid...
Interleukin-17 Leukapheresis Colitis, Ulcerative Humans C-Reactive Protein Adult Interleukin-6 Infliximab Male Prospective Studies Middle Aged Female Time Factors
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Infliximab trough levels and persistent vs transient antibodies measured early after induction predict long-term clinical remission in patients with inflammatory bowel disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Nov 27, 2017
BACKGROUND: The use of therapeutic drug monitoring has been proposed as a useful tool in the management of patients with loss of response to biological therapy in patients with inflammatory bowel disease.
Time Factors ROC Curve Colitis, Ulcerative Humans Drug Resistance Young Adult Infliximab Drug Monitoring Prospective Studies Adult Crohn Disease Antibodies Female Male Gastrointestinal Agents Aged Middle Aged Remission Induction
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Serum Interleukin-33 level in Saudi children with inflammatory bowel disease.

International journal of clinical and experimental pathology Dec 1, 2015
Interleukin-33 (IL-33) is a cytokine that belongs to the interleukin-1 family and has been shown to be associated with mucosal inflammation. The aim of this study was to determine the serum level of IL-33 in children with ulcerative colitis (UC) and ...
Age Factors Biological Products Colitis, Ulcerative Diagnosis, Differential Predictive Value of Tests C-Reactive Protein Crohn Disease Inflammation Mediators Up-Regulation Case-Control Studies Saudi Arabia Adolescent Child Humans Enzyme-Linked Immunosorbent Assay Prospective Studies Female Nephelometry and Turbidimetry Biomarkers Cross-Sectional Studies Prognosis Interleukin-33 Male Severity of Illness Index
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Seasonal variation in onset and relapse of IBD and a model to predict the frequency of onset, relapse, and severity of IBD based on artificial neural network.

International journal of colorectal disease May 15, 2015
BACKGROUND: Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was (1) to determine whether the frequency of onset and relapse of inflam...
Crohn Disease Weather Seasons Recurrence Middle Aged Severity of Illness Index Incidence Colitis, Ulcerative Humans Neural Networks, Computer Forecasting Female Adult Male
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Explainable artificial intelligence for prediction of refractory ulcerative colitis: analysis of a Japanese Nationwide Registry.

Annals of medicine Dec 1, 2025
OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is dependent on corticosteroid (CS) treatment. The diversity of disease pathophysiology necessitates optimal case-specific treatment selection. This study ...
Adult Male Middle Aged Colitis, Ulcerative Registries Remission Induction Japan Adrenal Cortex Hormones Machine Learning Prognosis Female Aged Humans Young Adult Artificial Intelligence
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Vedolizumab in inflammatory bowel disease: Real-world outcomes and their prediction with machine learning-the IG-IBD LIVE study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Jul 1, 2025
BACKGROUND AND AIMS: Real-world studies on vedolizumab in inflammatory bowel disease (IBD) are often limited by small sample size and short follow-up. In this study, we investigated the 2-year effectiveness and safety of vedolizumab in patients with ...
Gastrointestinal Agents Remission Induction Antibodies, Monoclonal, Humanized Colitis, Ulcerative Italy Machine Learning Crohn Disease Inflammatory Bowel Diseases Female Aged Young Adult Adult Male Middle Aged Humans Treatment Outcome
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Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis.

Inflammatory bowel diseases Jun 13, 2025
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by increased stool frequency, rectal bleeding, and urgency. To streamline the quantitative assessment of histopathology using the Nancy Index in UC patients, we...
Humans Neural Networks, Computer Artificial Intelligence Middle Aged Severity of Illness Index Deep Learning Colitis, Ulcerative Female Proof of Concept Study Young Adult Adult Male
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Identifying Lactylation-related biomarkers and therapeutic drugs in ulcerative colitis: insights from machine learning and molecular docking.

BMC pharmacology & toxicology May 13, 2025
BACKGROUND: Ulcerative colitis (UC), a chronic relapsing-remitting inflammatory bowel disease. Recent studies have shown that lactylation modifications may be involved in metabolic-immune interactions in intestinal inflammation through epigenetic reg...
Male Molecular Docking Simulation Transcriptome Humans Colitis, Ulcerative Machine Learning Biomarkers Female
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Radiomics prediction of surgery in ulcerative colitis refractory to medical treatment.

Techniques in coloproctology May 10, 2025
BACKGROUND: The surgeries in drug-resistant ulcerative colitis are determined by complex factors. This study evaluated the predictive performance of radiomics analysis on the basis of whether patients with ulcerative colitis in hospital were in the s...
Colitis, Ulcerative Predictive Value of Tests Rectum Radiomics Male Middle Aged Severity of Illness Index Humans Nomograms Retrospective Studies Tomography, X-Ray Computed Female Adult
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Accurate, Robust, and Scalable Machine Abstraction of Mayo Endoscopic Subscores From Colonoscopy Reports.

Inflammatory bowel diseases Mar 3, 2025
BACKGROUND: The Mayo endoscopic subscore (MES) is an important quantitative measure of disease activity in ulcerative colitis. Colonoscopy reports in routine clinical care usually characterize ulcerative colitis disease activity using free text descr...
Humans Male Middle Aged Colonoscopy Severity of Illness Index Colitis, Ulcerative Machine Learning Algorithms Female Adult
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