DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a n...
In the pathological diagnosis of colorectal cancer, the precise segmentation of glandular and cellular contours serves as the fundamental basis for achieving accurate clinical diagnosis. However, this task presents significant challenges due to compl...
Chloride channel accessory 1 (CLCA1) is considered a potential prognostic biomarker for colon adenocarcinoma (COAD). The objective of this research was to develop two pathomics models to predict CLCA1 expression from hematoxylin-eosin (H&E) stained p...
Journal of cancer research and clinical oncology
Jul 9, 2025
BACKGROUND: Colon cancer remains a leading cause of cancer-related mortality globally, highlighting the urgent need for advanced diagnostic methods to improve early detection and patient outcomes.
Lung and colon cancers (LCC) are among the foremost reasons for human death and disease. Early analysis of this disorder contains various tests, namely ultrasound (US), magnetic resonance imaging (MRI), and computed tomography (CT). Despite analytica...
After colorectal surgery, delayed gastric emptying (DGE) is a clinically significant postoperative complication that significantly lowers patients' quality of life. The evolving application of robotic surgery in gastrointestinal oncology continues to...
BACKGROUND: Postoperative complications in colorectal surgery can significantly impact patient outcomes and healthcare costs. Accurate prediction of these complications enables targeted perioperative management, improving patient safety and optimizin...
In histopathology, acquiring subcellular-level three-dimensional (3D) tissue structures efficiently and without damaging the tissues during serial sectioning and staining remains a formidable challenge. We address this by integrating holotomography w...
BACKGROUND: Malignant tumors are a major global health crisis, causing 25% of deaths in China, with lung, liver, thyroid, breast, and colon cancers being the most common. Understanding the factors influencing hospitalization costs for these cancers i...
Journal of gastroenterology and hepatology
Mar 31, 2025
BACKGROUND AND STUDY AIMS: Determining adenoma detection rate (ADR) and serrated polyp detection rate (SDR) can be challenging as they usually involve manual matching of colonoscopy and histology reports. This study aimed to validate a Natural Langua...
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