AIMC Topic: Computational Biology
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Lactylation associated biomarkers and immune infiltration in aortic dissection.
Scientific reports
Jul 1, 2025
Protein lactylation, a novel post-translational modification (PTM), has emerged as a critical factor in disease processes related to glycolysis and immune responses. However, its role in aortic dissection (AD) has yet to be thoroughly investigated. T...
Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.
Scientific reports
Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy.
Scientific reports
Jul 1, 2025
Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder affecting the orbit, potentially resulting in blindness. This study focused on the role of hypoxia in its pathogenesis through integrative bioinformatics and experimental validation. F...
Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis.
Scientific reports
Jul 1, 2025
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are closely related autoimmune diseases with shared mechanisms that remain unclear. This study aims to identify shared molecular signatures and hub genes underlying the co-occurrence of AS and...
A genetic algorithm-based ensemble model for efficiently identifying interleukin 6 inducing peptides.
Scientific reports
Jul 1, 2025
Interleukin-6 (IL-6) is a cytokine with diverse biological activities that contribute to a variety of physiologic and immune responses. IL-6-inducing peptides are the short protein fragments that are critical for playing a contributing role in biolog...
Comprehensive datasets for RNA design, machine learning, and beyond.
Scientific reports
Jul 1, 2025
RNA molecules are essential in regulating biological processes such as gene expression, cellular differentiation, and development. Accurately predicting RNA secondary structures and designing sequences that fold into specific configurations remain si...
Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis.
Scientific reports
Jul 1, 2025
Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore t...
RiNALMo: general-purpose RNA language models can generalize well on structure prediction tasks.
Nature communications
Jul 1, 2025
While RNA has recently been recognized as an interesting small-molecule drug target, many challenges remain to be addressed before we take full advantage of it. This emphasizes the necessity to improve our understanding of its structures and function...
Deep generalizable prediction of RNA secondary structure via base pair motif energy.
Nature communications
Jul 1, 2025
Deep learning methods have demonstrated great performance for RNA secondary structure prediction. However, generalizability is a common unsolved issue on unseen out-of-distribution RNA families, which hinders further improvement of the accuracy and r...
Spatial domain detection using contrastive self-supervised learning for spatial multi-omics technologies.
Genome research
Jul 1, 2025
Recent advances in spatially resolved single-omic and multi-omics technologies have led to the emergence of computational tools to detect and predict spatial domains. Additionally, histological images and immunofluorescence (IF) staining of proteins ...
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