AIMC Topic: Computational Biology

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Enhanced Protein Structural Class Prediction Using Effective Feature Modeling and Ensemble of Classifiers.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Protein Secondary Structural Class (PSSC) information is important in investigating further challenges of protein sequences like protein fold recognition, protein tertiary structure prediction, and analysis of protein functions for drug discovery. Id...
Machine Learning Computational Biology Amino Acid Sequence Protein Structure, Secondary Sequence Analysis, Protein Support Vector Machine Proteins Databases, Protein
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Drug-Target Interaction Prediction: End-to-End Deep Learning Approach.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
The discovery of potential Drug-Target Interactions (DTIs) is a determining step in the drug discovery and repositioning process, as the effectiveness of the currently available antibiotic treatment is declining. Although putting efforts on the tradi...
Pharmaceutical Preparations Amino Acid Sequence Neural Networks, Computer Machine Learning Humans Algorithms Deep Learning Drug Discovery Computational Biology Proteins Drug Repositioning
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Using Convolutional Neural Networks to Measure the Physiological Age of Caenorhabditis elegans.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Caenorhabditis elegans (C. elegans) is a popular and excellent model for studies of aging due to its short lifespan. Methods for precisely measuring the physiological age of C. elegans are critically needed, especially for antiaging drug screening an...
Logistic Models Microscopy Linear Models Caenorhabditis elegans Animals Aging Image Processing, Computer-Assisted Computational Biology Neural Networks, Computer
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A Deep Learning Framework for Gene Ontology Annotations With Sequence- and Network-Based Information.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Knowledge of protein functions plays an important role in biology and medicine. With the rapid development of high-throughput technologies, a huge number of proteins have been discovered. However, there are a great number of proteins without function...
Molecular Sequence Annotation Gene Ontology Computational Biology Proteins Amino Acid Sequence Software Algorithms Deep Learning Protein Interaction Maps
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NegStacking: Drug-Target Interaction Prediction Based on Ensemble Learning and Logistic Regression.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Drug-target interactions (DTIs) identification is an important issue of drug research, and many methods proposed to predict potential DTIs based on machine learning treat it as a binary classification problem. However, the number of known interacting...
Machine Learning Computer Simulation Computational Biology Logistic Models Drug Development
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Prediction of FMN Binding Sites in Electron Transport Chains Based on 2-D CNN and PSSM Profiles.

IEEE/ACM transactions on computational biology and bioinformatics Dec 8, 2021
Flavin mono-nucleotides (FMNs) are cofactors that hold responsibility for carrying and transferring electrons in the electron transport chain stage of cellular respiration. Without being facilitated by FMNs, energy production is stagnant due to the i...
Algorithms Deep Learning Computational Biology Binding Sites Neural Networks, Computer Electron Transport Position-Specific Scoring Matrices Flavin Mononucleotide
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An Improved Brain MRI Classification Methodology Based on Statistical Features and Machine Learning Algorithms.

Computational and mathematical methods in medicine Dec 7, 2021
In this paper, we have proposed a novel methodology based on statistical features and different machine learning algorithms. The proposed model can be divided into three main stages, namely, preprocessing, feature extraction, and classification. In t...
Algorithms Magnetic Resonance Imaging Image Interpretation, Computer-Assisted Brain Humans Brain Diseases Decision Trees Brain Neoplasms Neural Networks, Computer Neuroimaging Bayes Theorem Computational Biology Machine Learning
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A Multilayer Perceptron Neural Network Model to Classify Hypertension in Adolescents Using Anthropometric Measurements: A Cross-Sectional Study in Sarawak, Malaysia.

Computational and mathematical methods in medicine Dec 7, 2021
This study outlines and developed a multilayer perceptron (MLP) neural network model for adolescent hypertension classification focusing on the use of simple anthropometric and sociodemographic data collected from a cross-sectional research study in ...
Male Prevalence Adolescent Computational Biology Neural Networks, Computer Female Cross-Sectional Studies Humans Anthropometry Hypertension Malaysia Bayes Theorem Sociodemographic Factors
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Blood Pressure Model Based on Hybrid Feature Convolution Neural Network in Promoting Rehabilitation of Patients with Hypertensive Intracerebral Hemorrhage.

Computational and mathematical methods in medicine Dec 7, 2021
OBJECTIVE: Accurate prediction of the rise of blood pressure is essential for the hypertensive intracerebral hemorrhage. This study uses the hybrid feature convolution neural network to establish the blood pressure model instead of the traditional me...
Blood Pressure Antihypertensive Agents Pulse Wave Analysis Recurrence Models, Cardiovascular Intracranial Hemorrhage, Hypertensive Adult Male Middle Aged Computational Biology Algorithms Female Aged Humans Neural Networks, Computer Machine Learning
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Systems biology and machine learning approaches identify drug targets in diabetic nephropathy.

Scientific reports Dec 6, 2021
Diabetic nephropathy (DN), the leading cause of end-stage renal disease, has become a massive global health burden. Despite considerable efforts, the underlying mechanisms have not yet been comprehensively understood. In this study, a systematic appr...
Support Vector Machine Cluster Analysis MicroRNAs Regression Analysis Systems Biology Epigenesis, Genetic Signal Transduction Oligonucleotide Array Sequence Analysis Mice, Inbred DBA Kidney Cortex Kidney Medulla Principal Component Analysis Linear Models Male Chemistry, Pharmaceutical Global Health Microarray Analysis Humans Drug Design Machine Learning Gene Regulatory Networks Gene Expression Profiling Algorithms Mice Animals Diabetic Nephropathies Computational Biology
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