AIMC Topic: Cross-Over Studies
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The advantages of combination therapy on hypertension: development of immediate release perindopril-indapamide tablet and assessment of bioequivalence studies.
Pharmaceutical development and technology
Oct 13, 2015
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perind...
Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.
Clinical pharmacology in drug development
Oct 5, 2015
Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin doses. This phase 1, open-label, 2-sequence, 4-period crossover, randomiz...
Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule.
International journal for parasitology. Drugs and drug resistance
Sep 25, 2015
Despite the well established ivermectin activity against microfilaria, the success of human filariasis control programmes requires the use of a macrofilaricide compound. Different in vivo trials suggest that flubendazole (FLBZ), an anthelmintic benzi...
Colonoscopy with robotic steering and automated lumen centralization: a feasibility study in a colon model.
Endoscopy
Jun 30, 2015
BACKGROUND AND STUDY AIMS: We introduced a new platform for performing colonoscopy with robotic steering and automated lumen centralization (RS-ALC) and evaluated its technical feasibility.
Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.
Clinical pharmacology in drug development
Jun 8, 2015
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Fourier Analysis
Models, Biological
Male
Healthy Volunteers
London
Nonlinear Dynamics
Circadian Rhythm
Middle Aged
Selective Estrogen Receptor Modulators
Humans
Administration, Oral
Benzopyrans
Testosterone
Biomarkers
Cross-Over Studies
Drug Administration Schedule
Single-Blind Method
Young Adult
Estrogen Receptor beta
Adult
What device should be used for telementoring? Randomized controlled trial.
International journal of medical informatics
May 22, 2015
BACKGROUND AND OBJECTIVE: The paper analyzes behavioral patterns of mentors while using different mentoring devices to demonstrate the feasibility of multi-platform mentoring. The fundamental differences of devices supporting telementoring create thr...
Comparison of Coopdech®, CoPilot®, Intubrite®, and Macintosh laryngoscopes for tracheal intubation during pediatric cardiopulmonary resuscitation: a randomized, controlled crossover simulation trial.
European journal of pediatrics
May 21, 2015
UNLABELLED: The aim of the study was to compare the intubation times and success rates of various laryngoscopes during resuscitation in pediatric emergency intubation with uninterrupted chest compression on a standardized pediatric manikin model. Thi...
Does Robotic Telerounding Enhance Nurse-Physician Collaboration Satisfaction About Care Decisions?
Telemedicine journal and e-health : the official journal of the American Telemedicine Association
May 4, 2015
BACKGROUND: Delivering healthcare using remote robotic telepresence is an evolving practice in medical and surgical intensive critical care units and will likely have varied implications for work practices and working relationships in intensive care ...
Conventional Laparoscopic vs Robotic Training: Which is Better for Naive Users? A Randomized Prospective Crossover Study.
Journal of surgical education
Feb 14, 2015
OBJECTIVE: Robotic training (RT) using the da Vinci skills simulator and conventional training (CT) using a laparoscopic "training box" are both used to augment operative skills in minimally invasive surgery. The current study tests the hypothesis th...
Artificial intelligence driven 3D reconstruction for enhanced lung surgery planning.
Nature communications
May 1, 2025
The increasing complexity of lung surgeries necessitates the need for enhanced imaging support to improve the precision and efficiency of preoperative planning. Despite the promise of 3D reconstruction, clinical adoption remains limited due to time c...
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