Accurately segmenting and individualizing cells in scanning electron microscopy (SEM) images is a highly promising technique for elucidating tissue architecture in oncology. While current artificial intelligence (AI)-based methods are effective, erro...
With the increasing global prevalence of disabling hearing loss, speech enhancement technologies have become crucial for overcoming communication barriers and improving the quality of life for those affected. Multimodal learning has emerged as a powe...
BACKGROUND: Sarcopenia is associated with decreased survival in cervical cancer patients treated with radiotherapy. Cone-beam computed tomography (CBCT) was widely used in image-guided radiotherapy. Sarcopenia is assessed by the skeletal muscle index...
In bone-imaging research, in situ synchrotron radiation micro-computed tomography (SRµCT) mechanical tests are used to investigate the mechanical properties of bone in relation to its microstructure. Low-dose computed tomography (CT) is used to prese...
Lung cancer exhibits strong heterogeneity, and its early diagnosis and precise subtyping are of great importance, as they can increase the ability to deliver personalized medicines by tailoring therapy regimens. Tissue biopsy, albeit the gold standar...
Journal of chemical information and modeling
Apr 1, 2025
Allosteric compounds offer an alternative mode of inhibition to orthosteric compounds with opportunities for selectivity and noncompetition. Structure-based drug design (SBDD) of allosteric compounds introduces complications compared to their orthost...
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
The aaccurate prediction of enzymes with environment detoxification functions is crucial, not only to achieve a better understanding of bioremediation strategies, but also to alleviate environmental pollution. In the present study, a novel machine le...
Accurate accounting of greenhouse gases (GHGs) emissions from industrial wastewater treatment processes/plants with high organic concentration and fluctuating inflows is crucial for the calculation and management of carbon emissions. The impacts of w...
BACKGROUND: Chromatin loops are critical for the three-dimensional organization of the genome and gene regulation. Accurate identification of chromatin loops is essential for understanding the regulatory mechanisms in disease. However, current mainst...
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