BACKGROUND: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in th...
Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell c...
The journal of prevention of Alzheimer's disease
Feb 6, 2025
BACKGROUND: Mild cognitive impairment (MCI) and preclinical MCI (e.g., subjective cognitive decline, SCD) are considered risk states of dementia, such as Alzheimer's Disease (AD). However, it is challenging to accurately predict conversion from norma...
BACKGROUND: Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development of metabolomic technologies has enabled the capture of metabolic changes related to the progression of cirrhosis.
Neural networks : the official journal of the International Neural Network Society
Feb 1, 2025
The diagnosis of Alzheimer's disease (AD) based on visual features-informed by clinical knowledge has achieved excellent results. Our study endeavors to present an innovative and detailed deep learning framework designed to accurately predict the pro...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jan 30, 2025
INTRODUCTION: Machine learning (ML) helps diagnose the mild cognitive impairment-Alzheimer's disease (MCI-AD) spectrum. However, ML is fed with data unavailable in standard clinical practice. Thus, we tested a novel multi-step ML approach to predict ...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jan 27, 2025
INTRODUCTION: Current models of Alzheimer's disease (AD) progression assume a common pattern and pathology, oversimplifying the heterogeneity of clinical AD.
PURPOSE: Adaptive radiotherapy accounts for interfractional anatomic changes. We hypothesize that changes in the gross tumor volumes identified during daily scans could be analyzed using delta-radiomics to predict disease progression events. We evalu...
Application of single-cell/nucleus genomic sequencing to patient-derived tissues offers potential solutions to delineate disease mechanisms in humans. However, individual cells in patient-derived tissues are in different pathological stages, and henc...
International journal of chronic obstructive pulmonary disease
Jan 20, 2025
BACKGROUND: Chronic obstructive pulmonary disease (COPD) affects breathing, speech production, and coughing. We evaluated a machine learning analysis of speech for classifying the disease severity of COPD.
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