AIMC Topic: Disease Progression

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Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning.

International immunopharmacology
BACKGROUND: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in th...

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression.

Nature communications
Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell c...

Predicting cognitive decline: Deep-learning reveals subtle brain changes in pre-MCI stage.

The journal of prevention of Alzheimer's disease
BACKGROUND: Mild cognitive impairment (MCI) and preclinical MCI (e.g., subjective cognitive decline, SCD) are considered risk states of dementia, such as Alzheimer's Disease (AD). However, it is challenging to accurately predict conversion from norma...

Machine learning-based plasma metabolomics for improved cirrhosis risk stratification.

BMC gastroenterology
BACKGROUND: Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development of metabolomic technologies has enabled the capture of metabolic changes related to the progression of cirrhosis.

Multi-knowledge informed deep learning model for multi-point prediction of Alzheimer's disease progression.

Neural networks : the official journal of the International Neural Network Society
The diagnosis of Alzheimer's disease (AD) based on visual features-informed by clinical knowledge has achieved excellent results. Our study endeavors to present an innovative and detailed deep learning framework designed to accurately predict the pro...

Predicting conversion in cognitively normal and mild cognitive impairment individuals with machine learning: Is the CSF status still relevant?

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Machine learning (ML) helps diagnose the mild cognitive impairment-Alzheimer's disease (MCI-AD) spectrum. However, ML is fed with data unavailable in standard clinical practice. Thus, we tested a novel multi-step ML approach to predict ...

An unsupervised learning approach for clustering joint trajectories of Alzheimer's disease biomarkers: An application to ADNI Data.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Current models of Alzheimer's disease (AD) progression assume a common pattern and pathology, oversimplifying the heterogeneity of clinical AD.

Delta-Radiomics Using Machine Learning Classifiers With Auxiliary Data Sets to Predict Disease Progression During Magnetic Resonance-Guided Radiotherapy in Adrenal Metastases.

JCO clinical cancer informatics
PURPOSE: Adaptive radiotherapy accounts for interfractional anatomic changes. We hypothesize that changes in the gross tumor volumes identified during daily scans could be analyzed using delta-radiomics to predict disease progression events. We evalu...

Inferring disease progression stages in single-cell transcriptomics using a weakly supervised deep learning approach.

Genome research
Application of single-cell/nucleus genomic sequencing to patient-derived tissues offers potential solutions to delineate disease mechanisms in humans. However, individual cells in patient-derived tissues are in different pathological stages, and henc...