AIMC Topic: Doxorubicin
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Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sep 7, 2023
Doxorubicin-induced cardiomyopathy (DIC) brings tough clinical challenges as well as continued demand in developing agents for adjuvant cardioprotective therapies. Here, a zebrafish phenotypic screening with deep-learning assisted multiplex cardiac f...
Numerical learning of deep features from drug-exposed cell images to calculate IC50 without staining.
Scientific reports
Apr 22, 2022
To facilitate rapid determination of cellular viability caused by the inhibitory effect of drugs, numerical deep learning algorithms was used for unlabeled cell culture images captured by a light microscope as input. In this study, A549, HEK293, and ...
Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery.
Science robotics
Jan 19, 2022
We propose two-dimensional poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their high-speed (15 to 23 micrometer per second; 9.5 ± 5.4 body lengths per second) swimming in...
Magnetic Biohybrid Microrobot Multimers Based on Cells for Enhanced Targeted Drug Delivery.
ACS applied materials & interfaces
Jan 12, 2022
Magnetic micro-/nanorobots have been regarded as a promising platform for targeted drug delivery, and tremendous strategies have been developed in recent years. However, realizing precise and efficient drug delivery in vivo still remains challenging,...
Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment.
ACS nano
Oct 19, 2021
Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (., encapsulation and release) in biological applicati...
Precise Control of Customized Macrophage Cell Robot for Targeted Therapy of Solid Tumors with Minimal Invasion.
Small (Weinheim an der Bergstrasse, Germany)
Sep 12, 2021
Injecting micro/nanorobots into the body to kill tumors is one of the ultimate ambitions for medical nanotechnology. However, injecting current micro/nanorobots based on 3D-printed biocompatible materials directly into blood vessels for targeted ther...
The Value of Convolutional Neural Network-Based Magnetic Resonance Imaging Image Segmentation Algorithm to Guide Targeted Controlled Release of Doxorubicin Nanopreparation.
Contrast media & molecular imaging
Jul 26, 2021
There was an investigation of the auxiliary role of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image segmentation algorithm in MRI image-guided targeted drug therapy of doxorubicin nanomaterials so that the value of d...
Antibiotics, Antineoplastic
Nanoparticle Drug Delivery System
Male
Prognosis
Doxorubicin
Liver Neoplasms
Middle Aged
Humans
Female
Image Processing, Computer-Assisted
Case-Control Studies
Drug Liberation
Neural Networks, Computer
Aged
Follow-Up Studies
Delayed-Action Preparations
Algorithms
Adult
Magnetic Resonance Imaging
Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability.
ACS applied materials & interfaces
Apr 20, 2021
Therapeutic drug delivery microrobots capable of accurate targeting using an electromagnetic actuation (EMA) system are being developed. However, these drug delivery microrobots include a large number of magnetic nanoparticles (MNPs) for accurate EMA...
Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells.
Scientific reports
Apr 12, 2021
Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delive...
Magnetically actuated intelligent hydrogel-based child-parent microrobots for targeted drug delivery.
Journal of materials chemistry. B
Jan 5, 2021
Small intestine-targeted drug delivery by oral administration has aroused the growing interest of researchers. In this work, the child-parent microrobot (CPM) as a vehicle protects the child microrobots (CMs) under a gastric acid environment and rele...
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