AIMC Topic: Drug Resistance, Multiple, Bacterial

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Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii.

Nature chemical biology May 25, 2023
Acinetobacter baumannii is a nosocomial Gram-negative pathogen that often displays multidrug resistance. Discovering new antibiotics against A. baumannii has proven challenging through conventional screening approaches. Fortunately, machine learning ...
Microbial Sensitivity Tests Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Animals Mice Deep Learning Acinetobacter baumannii
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First-line drug resistance profiling of : a machine learning approach.

AMIA ... Annual Symposium proceedings. AMIA Symposium Feb 21, 2022
The persistence and emergence of new multi-drug resistant Mycobacterium tuberculosis (M. tb) strains continues to advance the devastating tuberculosis (TB) epidemic. Robust systems are needed to accurately and rapidly perform drug-resistance profilin...
Antitubercular Agents Humans Tuberculosis Machine Learning Mycobacterium tuberculosis Drug Resistance, Multiple, Bacterial
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Accurate and rapid prediction of tuberculosis drug resistance from genome sequence data using traditional machine learning algorithms and CNN.

Scientific reports Feb 14, 2022
Effective and timely antibiotic treatment depends on accurate and rapid in silico antimicrobial-resistant (AMR) predictions. Existing statistical rule-based Mycobacterium tuberculosis (MTB) drug resistance prediction methods using bacterial genomic s...
Tuberculosis, Multidrug-Resistant Whole Genome Sequencing Mycobacterium tuberculosis Data Accuracy Drug Resistance, Multiple, Bacterial Cohort Studies Humans Mutation Phenotype Genome, Bacterial Antitubercular Agents Prognosis Phylogeny Deep Learning Microbial Sensitivity Tests
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Machine learning models predicting multidrug resistant urinary tract infections using "DsaaS".

BMC bioinformatics Aug 21, 2020
BACKGROUND: The scope of this work is to build a Machine Learning model able to predict patients risk to contract a multidrug resistant urinary tract infection (MDR UTI) after hospitalization. To achieve this goal, we used different popular Machine L...
Neural Networks, Computer Machine Learning Algorithms Female Humans Urinary Tract Infections Models, Biological ROC Curve Support Vector Machine Area Under Curve Italy Aged Male Middle Aged Drug Resistance, Multiple, Bacterial
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Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.

Scientific reports Mar 26, 2020
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (M.tb), causes highest number of deaths globally for any bacterial disease necessitating novel diagnosis and treatment strategies. High-throughput sequencing methods genera...
Bacterial Proteins Mutation Tuberculosis, Multidrug-Resistant Molecular Dynamics Simulation Molecular Docking Simulation Drug Resistance, Multiple, Bacterial Polymorphism, Single Nucleotide Bayes Theorem Mycobacterium tuberculosis Genes, Bacterial Genes, MDR Humans Artificial Intelligence Machine Learning Algorithms
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Harnessing robotic automation and web-based technologies to modernize scientific outreach.

PLoS biology Jun 26, 2019
Technological breakthroughs in the past two decades have ushered in a new era of biomedical research, turning it into an information-rich and technology-driven science. This scientific revolution, though evident to the research community, remains opa...
Automation Teaching Education Community-Institutional Relations Robotics Internet Schools Information Dissemination Male Students Drug Resistance, Multiple, Bacterial Adolescent Humans Technology Female
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Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Scientific reports Oct 26, 2018
With the increased prevalence of multidrug-resistant Gram-negative bacteria, the use of colistin and other last-line antimicrobials is being revisited clinically. As a result, there has been an emergence of colistin-resistant bacterial species, inclu...
Mass Spectrometry Databases, Factual Area Under Curve Humans Drug Resistance, Multiple, Bacterial Acinetobacter baumannii Machine Learning ROC Curve Colistin Anti-Bacterial Agents Klebsiella pneumoniae Glycolipids
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Dalbavancin in-vitro activity obtained against Gram-positive clinical isolates causing bone and joint infections in US and European hospitals (2011-2016).

International journal of antimicrobial agents Dec 23, 2017
BACKGROUND: Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate for the treatment ...
United States Staphylococcus aureus Europe Staphylococcal Infections Streptococcal Infections Enterococcus faecalis Humans Teicoplanin Anti-Bacterial Agents Osteomyelitis Viridans Streptococci Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial
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Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens.

Molecules (Basel, Switzerland) Dec 20, 2017
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, includin...
Naphthoquinones Rhizopus Tracheophyta Microbial Sensitivity Tests Drug Synergism Umbilical Veins Plant Oils Oils, Volatile Erythrocytes Candida Drug Resistance, Multiple, Bacterial Humans Endothelial Cells Antifungal Agents Cell Survival Anti-Bacterial Agents Drug Resistance, Multiple, Fungal Liposomes
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Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.

Molecules (Basel, Switzerland) Dec 8, 2017
In view of the pressing need to identify new antibacterial agents able to combat multidrug-resistant bacteria, we investigated a series of fused selenazolinium derivatives (-) regarding their in vitro antimicrobial activities against 25 ESKAPE-pathog...
Isoindoles Organoselenium Compounds Anti-Bacterial Agents Bacteria Humans Microbial Sensitivity Tests Structure-Activity Relationship Drug Resistance, Multiple, Bacterial Molecular Structure Oxidative Stress Azoles
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