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An integrated bioinformatics and machine learning approach to identifying biomarkers connecting parkinson's disease with purine metabolism-related genes.

BMC neurology
BACKGROUND: Parkinson's disease (PD), a prevalent neurodegenerative disorder in the aging population, poses significant challenges in unraveling its pathogenesis and progression. A key area of investigation is the disruption of oncological metabolic ...

Artificial intelligence based automatic classification, annotation, and measurement of the fetal heart using HeartAssist.

Scientific reports
This study evaluated the feasibility of HeartAssist, a novel automated tool designed for classification of fetal cardiac views, annotation of cardiac structures, and measurement of cardiac parameters. Unlike previous AI tools that primarily focused o...

A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease.

Scientific reports
The heterogeneity of cerebral small vessel disease (CSVD) with mild cognitive impairment (MCI) presents a challenge for diagnosis and classification. This study aims to propose a multimodal magnetic resonance imaging (MRI)-based machine learning fram...

Federated learning with differential privacy for breast cancer diagnosis enabling secure data sharing and model integrity.

Scientific reports
In the digital age, privacy preservation is of paramount importance while processing health-related sensitive information. This paper explores the integration of Federated Learning (FL) and Differential Privacy (DP) for breast cancer detection, lever...

Machine learning approaches for assessing medication transfer to human breast milk.

Journal of pharmacokinetics and pharmacodynamics
The human milk/plasma (M/P) drug concentration ratio is crucial in pharmacology, especially for breastfeeding mothers undergoing treatment. It determines the extent to which drugs ingested by the mother pass into breast milk, potentially affecting th...

Comparing machine learning models for predicting preoperative DVT incidence in elderly hypertensive patients with hip fractures: a retrospective analysis.

Scientific reports
Hip fractures in the elderly present a significant public health challenge globally, especially among patients with hypertension, who are at an increased risk of developing preoperative deep vein thrombosis (DVT). DVT not only heightens surgical risk...

Investigating long-term risk of aortic aneurysm and dissection from fluoroquinolones and the key contributing factors using machine learning methods.

Scientific reports
The connection between fluoroquinolones and severe heart conditions, such as aortic aneurysm (AA) and aortic dissection (AD), has been acknowledged, but the full extent of long-term risks remains uncertain. Addressing this knowledge deficit, a retros...

Barriers to the widespread adoption of diagnostic artificial intelligence for preventing antimicrobial resistance.

Scientific reports
Currently, antimicrobial resistance (AMR) poses a major public health challenge. The emergence of AMR, which significantly threatens public health, is primarily due to the overuse of antimicrobial agents. This study explored the possibility that the ...

Fabric integrated wearable glove with a twisted string actuator for manual handling tasks.

Scientific reports
Wearable robotic gloves with grip-assistive functionality offer a promising solution for high-intensity manual tasks. However, achieving a balance among lightweight design, adequate force generation, and dexterous hand movement in wearable robotic gl...

Predicting cerebral infarction and transient ischemic attack in healthy individuals and those with dysmetabolism: a machine learning approach combined with routine blood tests.

Scientific reports
Ischemic cerebral infarction is the most prevalent type of stroke, causing significant disability and death worldwide. Transient ischemic attack (TIA) is a strong predictor of subsequent stroke. Individuals with dysmetabolism, such as hypertension, h...