AIMC Topic: Gene Ontology
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Network-based approach identifies key genes associated with tumor heterogeneity in HPV positive and negative head and neck cancer patients.
Scientific reports
Aug 7, 2025
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...
A deep ensemble framework for human essential gene prediction by integrating multi-omics data.
Scientific reports
Jul 21, 2025
Essential genes are necessary for the survival or reproduction of a living organism. The prediction and analysis of gene essentiality can advance our understanding of basic life and human diseases, and further boost the development of new drugs. We p...
Prediction of hub genes in pulpal inflammation and regeneration using autoencoders and a generative AI approach.
Scientific reports
Jul 19, 2025
Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. This study employs a generative AI a...
Integrating machine learning and bioinformatics approaches to identify novel diagnostic gene biomarkers for diabetic mice.
Scientific reports
Jul 2, 2025
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
Identification of aging-related biomarkers and immune infiltration analysis in renal stones by integrated bioinformatics analysis.
Scientific reports
Jul 1, 2025
Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore t...
ProFun-SOM: Protein Function Prediction for Specific Ontology Based on Multiple Sequence Alignment Reconstruction.
IEEE transactions on neural networks and learning systems
May 2, 2025
Protein function prediction is crucial for understanding species evolution, including viral mutations. Gene ontology (GO) is a standardized representation framework for describing protein functions with annotated terms. Each ontology is a specific fu...
Machine learning based identification of anoikis related gene classification patterns and immunoinfiltration characteristics in diabetic nephropathy.
Scientific reports
May 1, 2025
Anoikis and immune cell infiltration are pivotal factors in the pathophysiological mechanism of diabetic nephropathy (DN), yet a comprehensive understanding of the mechanism is lacking. This work aimed to pinpoint distinctive anoikis-related genes (A...
UBTD2 protein molecules emerges as a key prognostic protein marker in glioma: Insights from integrated omics and machine learning analysis of GRM7, NCAPG, CEP55, and other biomarkers.
International journal of biological macromolecules
Apr 24, 2025
Glioma is a malignant brain tumor with poor prognosis, and there is an urgent need to find effective biomarkers for early diagnosis and treatment. The aim of this study was to explore the potential of UBTD2 as a key prognostic protein marker for glio...
Identifying disease progression biomarkers in metabolic associated steatotic liver disease (MASLD) through weighted gene co-expression network analysis and machine learning.
Journal of translational medicine
Apr 24, 2025
BACKGROUND: Metabolic Associated Steatotic Liver Disease (MASLD), encompassing conditions simple liver steatosis (MAFL) and metabolic associated steatohepatitis (MASH), is the most prevalent chronic liver disease. Currently, the management of MASLD i...
New and revised gene ontology biological process terms describe multiorganism interactions critical for understanding microbial pathogenesis and sequences of concern.
Journal of biomedical semantics
Mar 21, 2025
BACKGROUND: There is a new framework from the United States government for screening synthetic nucleic acids. Beginning in October of 2026, it calls for the screening of sequences 50 nucleotides or greater in length that are known to contribute to pa...
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