AIMC Topic: Glutathione

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Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.

Clinical nutrition (Edinburgh, Scotland) Dec 12, 2017
BACKGROUND & AIMS: Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administratio...
Coronary Disease Melatonin Cholesterol, HDL Glutathione Diabetes Mellitus, Type 2 Antioxidants Insulin Oxidative Stress Aged, 80 and over C-Reactive Protein Blood Pressure Female Male Double-Blind Method Aged Middle Aged Nitric Oxide Humans Blood Glucose Malondialdehyde Biomarkers
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Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

Oxidative medicine and cellular longevity Dec 28, 2015
Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells up...
NF-kappa B Anti-Inflammatory Agents Angiogenesis Inhibitors Reactive Oxygen Species Neovascularization, Pathologic Heme Oxygenase-1 Glutathione Matrix Metalloproteinase 9 Intercellular Adhesion Molecule-1 Tumor Necrosis Factor-alpha Antioxidants Inflammation Signal Transduction Humans NF-E2-Related Factor 2 Angiogenesis Inducing Agents Basidiomycota Endothelial Cells
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Machine Learning-Enabled Time-Resolved Nanozyme-Encoded Recognition of Endogenous Mercaptans for Disease Diagnosis.

Analytical chemistry May 20, 2025
With their important role in regulating intracellular redox balance and maintaining cell homeostasis, endogenous mercaptans are recognized as biomarkers of many diseases in clinical practice, and thus establishing efficient yet simple methods to dist...
Glutathione Benzidines Humans Machine Learning Sulfhydryl Compounds Homocysteine
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Machine learning-assisted surface-enhanced raman spectroscopy for the rapid determination of the glutathione redox ratio.

The Analyst May 12, 2025
Rapid and accurate detection of glutathione in its reduced (GSH) and oxidized (GSSG) forms is essential for monitoring oxidative stress in biological systems. Oxidative stress is a key indicator of various diseases, and glutathione plays a vital role...
Machine Learning Algorithms Oxidation-Reduction Glutathione Glutathione Disulfide Spectrum Analysis, Raman Support Vector Machine
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Hepatoprotective Activity of Water Extracts from Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes) Against Tert-Butyl Hydroperoxide-Induced Oxidative Liver Injury in Primary Cultured Rat Hepatocytes.

International journal of medicinal mushrooms Jan 1, 2015
We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC50s) of I...
tert-Butylhydroperoxide Basidiomycota Chemical and Drug Induced Liver Injury Protective Agents Humans Hepatocytes Malondialdehyde Cells, Cultured Alanine Transaminase Rats, Sprague-Dawley Animals Glutathione Lipid Peroxidation Oxidative Stress Plant Extracts Rats
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