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Graft Rejection

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Effect of the vascularized bone components on the survival of vascularized composite allografts.

The Journal of surgical research
BACKGROUND: Vascularized composite allograft (VCA), such as hand and face allograft, contains a vascularized bone component that may provide an immunologic benefit and induce tolerance for the simultaneous inclusion of marrow cells and a marrow micro...

Efficacy of Platelet-Rich Plasma on Fat Grafts in the Repair of Tympanic Membrane Perforations: An Experimental Study.

The journal of international advanced otology
OBJECTIVE: We investigated the use of autologous platelet-rich plasma (PRP) to improve the success rate of fat graft myringoplasty in perforated tympanic membranes of rats.

High soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts.

The International journal of artificial organs
INTRODUCTION: Serum soluble CD30 (sCD30), a 120-kD glycoprotein that belongs to the tumor necrosis factor receptor family, has been suggested as a marker of rejection in kidney transplant patients. The aim of this study was to evaluate the relationsh...

Integrative Analysis of Proteomics Data to Obtain Clinically Relevant Markers.

Methods in molecular biology (Clifton, N.J.)
The analysis of proteomics data can be significantly challenging. Beyond the technical challenges of accurately identifying and quantifying peptides, identifying the most biologically coherent set of biomarkers can be a particularly daunting step. In...

A dynamic model for predicting graft function in kidney recipients' upcoming follow up visits: A clinical application of artificial neural network.

International journal of medical informatics
BACKGROUND: Predicting the function of transplanted kidneys would help clinicians in individualized medical interventions. We aimed to develop and validate a predictive tool for a future value of estimated glomerular filtration rate (eGFR) at upcomin...

The future is coming: promising perspectives regarding the use of machine learning in renal transplantation.

Jornal brasileiro de nefrologia
INTRODUCTION: The prediction of post transplantation outcomes is clinically important and involves several problems. The current prediction models based on standard statistics are very complex, difficult to validate and do not provide accurate predic...

Diagnosis of T-cell-mediated kidney rejection in formalin-fixed, paraffin-embedded tissues using RNA-Seq-based machine learning algorithms.

Human pathology
Molecular diagnosis is being increasingly used in transplant pathology to render more objective and quantitative determinations that also provide mechanistic and prognostic insights. This study performed RNA-Seq on biopsies from kidneys with stable f...