AIMC Topic: Kidney Tubules

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Artificial intelligence for predicting interstitial fibrosis and tubular atrophy using diagnostic ultrasound imaging and biomarkers.

BMJ health & care informatics Mar 17, 2025
BACKGROUND: Chronic kidney disease (CKD) is a global health concern characterised by irreversible renal damage that is often assessed using invasive renal biopsy. Accurate evaluation of interstitial fibrosis and tubular atrophy (IFTA) is crucial for ...
Atrophy Renal Insufficiency, Chronic Retrospective Studies Fibrosis Female Kidney Tubules Aged Ultrasonography ROC Curve Male Middle Aged Artificial Intelligence Machine Learning Biomarkers Humans
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A novel automated method for comprehensive renal cast quantification from rat kidney sections using QuPath.

American journal of physiology. Renal physiology Dec 24, 2024
The presence of tubular casts within the kidney serves as an important feature when assessing the degree of renal injury. Quantification of renal tubular casts has been historically difficult due to varying cast morphologies, protein composition, and...
Software Female Animals Machine Learning Rats, Sprague-Dawley Disease Models, Animal Image Interpretation, Computer-Assisted Automation Male Kidney Rats Kidney Tubules Rats, Inbred Dahl
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Deep-learning model for evaluating histopathology of acute renal tubular injury.

Scientific reports Apr 19, 2024
Tubular injury is the most common cause of acute kidney injury. Histopathological diagnosis may help distinguish between the different types of acute kidney injury and aid in treatment. To date, a limited number of study has used deep-learning models...
Kidney Tubules Necrosis Acute Kidney Injury Animals Kidney Cisplatin Deep Learning Mice
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Evaluating tubulointerstitial compartments in renal biopsy specimens using a deep learning-based approach for classifying normal and abnormal tubules.

PloS one Jul 11, 2022
Renal pathology is essential for diagnosing and assessing the severity and prognosis of kidney diseases. Deep learning-based approaches have developed rapidly and have been applied in renal pathology. However, methods for the automated classification...
Nephritis, Interstitial Kidney Biopsy Kidney Tubules Humans Kidney Transplantation Deep Learning
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Clinical Significance of Urinary Biomarkers in Patients With Primary Focal Segmental Glomerulosclerosis.

The American journal of the medical sciences Dec 30, 2017
BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is often accompanied with tubulointerstitial lesion. This study aimed to assess the role of urinary biomarkers in predicting tubulointerstitial lesion and treatment response in FSGS patients.
Adult Humans Lipocalin-2 Acetylglucosaminidase Sensitivity and Specificity Biomarkers Glomerulosclerosis, Focal Segmental Kidney Tubules Male Female Hepatitis A Virus Cellular Receptor 1 Retinol-Binding Proteins
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Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Nephritis Enzyme-Linked Immunosorbent Assay Kidney Tubules Apoptosis Cell Migration Assays Lipopolysaccharides Ginsenosides Phosphatidylinositol 3-Kinases Humans Proto-Oncogene Proteins c-akt Cytokines Cell Survival Cell Line Analysis of Variance Blotting, Western Reproducibility of Results Protective Agents Reactive Oxygen Species Anti-Inflammatory Agents Epithelial Cells
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Imatinib Increases Serum Creatinine by Inhibiting Its Tubular Secretion in a Reversible Fashion in Chronic Myeloid Leukemia.

Clinical lymphoma, myeloma & leukemia Dec 20, 2015
BACKGROUND: Monitoring renal function is important in imatinib-treated patients with chronic myeloid leukemia because serum creatinine may increase during the course of therapy. The mechanism of this increase and its reversibility on treatment cessat...
Humans Retrospective Studies Kidney Function Tests Young Adult Case-Control Studies Female Male Kidney Tubules Creatinine Adult Treatment Outcome Imatinib Mesylate Aged Middle Aged Drug Substitution Leukemia, Myelogenous, Chronic, BCR-ABL Positive Glomerular Filtration Rate Protein Kinase Inhibitors Antineoplastic Agents
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Deep learning-based histopathologic segmentation of peritubular capillaries in kidney transplant biopsies.

Computers in biology and medicine Jul 1, 2025
BACKGROUND: Assessing the extent of inflammation in peritubular capillaries (PTCs) is important for diagnosing antibody-mediated rejection in kidney transplant biopsies. However, this assessment is time-consuming and suffers from interobserver variab...
Humans Kidney Transplantation Graft Rejection Biopsy Kidney Tubules Capillaries Male Deep Learning Image Processing, Computer-Assisted
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