CRISPR/Cas9 is a powerful genome editing tool, but its clinical application is hindered by off-target effects. Accurate computational prediction of these unintended edits is crucial for ensuring the safety and efficacy of therapeutic applications. Wh...
Anhydroicaritin (AHI), a chemically characterized prenylated flavonoid, exhibits strong and selective cytotoxicity against estrogen receptor-positive (ER+) breast cancer cells. In this study, we aimed to elucidate its molecular and cellular toxicolog...
Biochemical and biophysical research communications
Nov 11, 2025
Osteoarthritis (OA) is the most common degenerative joint disease, and the complexity of its molecular mechanisms has hindered the development of effective diagnostic and therapeutic strategies. In this study, we integrated five independent OA RNA-se...
Journal of the American Heart Association
Nov 11, 2025
BACKGROUND: Despite the established link between metabolic syndrome (MetS) and stroke incidence, the effects of dynamic and cumulative MetS scores on stroke risk among middle-aged and older populations in China remain inadequately explored. Furthermo...
Proceedings of the National Academy of Sciences of the United States of America
Nov 11, 2025
Histological images offer a wealth of data. Mining these data holds significant potential for enhancing disease diagnosis and prognosis, though challenges remain, especially in noncancer contexts. In this study, we developed a statistical framework t...
Journal of speech, language, and hearing research : JSLHR
Nov 10, 2025
PURPOSE: Characterizing speech-in-noise recognition is fundamental to both clinical audiology and hearing research. Current methods rely on human speech recordings and human testers. However, modern artificial intelligence tools could automate both s...
The rapid development and integration of artificial intelligence (AI), including predictive, generative, and emerging agentic tools, into cardiovascular and stroke care is outpacing traditional evaluation frameworks and the generation of robust clini...
Risk stratification of patients with chest pain has traditionally focused on identifying obstructive coronary artery disease (CAD). Using this traditional approach, many symptomatic individuals are found to have nonobstructive CAD. The 2021 American ...
Developing a sensitive analytical platform for monitoring tiopronin (MPG), its metabolite 2-mercaptopropionic acid (MPA), and the key liver biomarker glutathione (GSH) is crucial for liver health assessment. Here, an artificial intelligence-assisted ...
The rapid development of machine learning (ML) and deep learning (DL) methods provides new opportunities for innovative drug discovery. While these techniques are widely used in docking organic molecules (drugs) with protein, an evaluation of the per...
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