Journal of pharmacokinetics and pharmacodynamics
Sep 22, 2025
Automatic differentiation (AD), a key method for accurately and efficiently computing derivatives in modern machine learning, is now implemented in Phoenix® NLME™ 8.6 for the first time and applied to the first-order conditional estimation extended l...
OBJECTIVE: To investigate the causal relationship between serotonin levels, adenosine deaminase (ADA) activity and multiple sclerosis (MS) progression using an integrative multi-omics approach.
BACKGROUND: Early prediction of treatment outcomes for patients with multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) undergoing extended therapy is crucial for enhancing clinical prognoses and preventing the transmission of this ...
Over the last 25 years, the health care sector has undergone a digital transformation; health issues and medical conditions are increasingly managed with the support of digital health technology. The internet has transformed the boundaries around phy...
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare disease with no accurate prognostic tools to predict the prognosis of patients.
BACKGROUND: Large language models (LLMs) such as ChatGPT (OpenAI) and Gemini (Google) are increasingly explored for their potential in medical diagnostics, including neurology. Their real-world applicability remains inadequately assessed, particularl...
Diabetes affects >10% of adults worldwide and is caused by impaired production or response to insulin, resulting in chronic hyperglycemia. Pancreatic islet β-cells are the sole source of endogenous insulin, and our understanding of β-cell dysfunction...
BACKGROUND: Manufacturer-defined AI thresholds for chest x-ray (CXR) often lack customization options. Threshold optimization strategies utilizing users' clinical real-world data along with pathology-enriched validation data may better address subgro...
. The compound muscle action potential (CMAP) scan contains a muscle's detailed stimulus-activation information and thereby can be used for motor unit number estimation (MUNE). Due to the challenges in accurately obtaining the motor unit numbers from...
Exosomes are critical biomarkers for early cancer diagnosis and prognosis due to their rich biological information. Nevertheless, analyzing exosomal biomarkers comprehensively remains challenging. Surface-enhanced Raman scattering (SERS) has been emp...
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