Several computational methods have been developed to construct single-cell pseudotime embeddings for extracting the temporal order of transcriptional cell states from time-series scRNA-seq datasets. However, existing methods suffer from low predictiv...
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is potentially curative for hematologic malignancies but is frequently complicated by relapse and immune-mediated complications, such as graft-versus-host disease (GVHD). Emerging ...
Clinical risk calculators consider sex as a binary variable. However, sex is a complex trait with anatomic, physiologic, and metabolic attributes that are not easily summarized in this manner [1]. We propose a continuous representation of sex, the EC...
BACKGROUND: Individualized prediction of health outcomes supports clinical medicine and decision making. Our primary objective was to offer a comprehensive survey of methods for the dynamic prediction of Alzheimer's disease (AD), encompassing both co...
Reproductive biology and endocrinology : RB&E
Jul 17, 2025
BACKGROUND: Conservative treatment remains a viable option for selected patients with ectopic pregnancy (EP), but failure may lead to rupture and serious complications. Currently, serum β-hCG is the main predictor for treatment outcomes, yet its accu...
BACKGROUND: Oral microbiota is a major etiological factor in the development of dental caries. Next-generation sequencing techniques have been widely used, generating vast amounts of data which is underexplored. The advancement of artificial intellig...
BACKGROUND: Clostridioides difficile is a major cause of hospital-acquired diarrhea and a driver of nosocomial outbreaks, yet rapid, accurate ribotype identification remains challenging. We sought to develop a MALDI-TOF MS-based workflow coupled with...
BACKGROUND: With the rapid development of digital transformation driven by big data and artificial intelligence in China, the field of public health is undergoing profound transformations. This study introduces technological innovation as a mediating...
BACKGROUND: Unplanned postoperative intensive care unit admissions (UIAs) are rare events that cause significant challenges to perioperative workflow. We describe the development of a machine-learning derived model to predict UIAs using only widely u...
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative condition, the effect of obesity on PD remains controversial. We aimed to investigate the associations of obesity patterns on PD and all-cause mortality, while developing machine l...
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