Artificial intelligence (AI) methods for digital pathology have tremendous potential to improve cancer diagnostics, biomarkers, and ultimately patient care. These AI methods, if marketed and sold, require authorisation or clearance as in vitro diagno...
Journal of chemical information and modeling
Jul 4, 2025
Super-enhancers (SEs) are cis-regulatory elements that play crucial roles in gene expression and are implicated in diseases such as cancer and Alzheimer's. Traditional identification methods rely on ChIP-seq experiments, which are costly and time-con...
Journal of chemical information and modeling
Jul 4, 2025
In recent years, virtual screening of ultralarge (10) libraries of synthetically accessible compounds (uHTVS) became a popular approach in hit identification. With AI-assisted virtual screening workflows, such as Deep Docking, these protocols might b...
British journal of hospital medicine (London, England : 2005)
Jul 4, 2025
The opioid crisis presents a significant burden to patients and healthcare systems. Orthopaedic surgery involves treating patients with significant pain demands, therefore opioid stewardship in this specialty is an important area in targeting the opi...
In the AlphaFold era, there is a significant momentum in predicting protein structures, functionality, and mutational hotspots from deep learning approaches. In this review, we highlight how structural information is only a starting point in understa...
BACKGROUND: The complex pathogenesis of Alzheimer's disease (AD) has resulted in limited current biomarkers for its classification and diagnosis, necessitating further investigation into reliable universal biomarkers or combinations.
BACKGROUND: Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and preliminary validation methods to...
BACKGROUND: The majority of individuals with chronic stroke have residual upper extremity (UE) disability which they cite as their greatest barrier to recovery. Using orthoses, robotic devices, and functional electrical stimulation (FES) represent re...
BMC medical informatics and decision making
Jul 4, 2025
BACKGROUND: The incidence of intensive care unit (ICU) admissions and the corresponding mortality rates among cancer patients are both high. However, the existing scoring systems all lack specificity. This research seeks to establish and validate a p...
OBJECTIVE: With survival steadily improving among people living with HIV(PLWH), quality of life (QoL) has emerged as the ultimate benchmark of therapeutic success. We therefore aimed to develop and validate machine learning models that predict QoL tr...
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