Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
OBJECTIVE: Ontologies are essential for representing the knowledge of a domain. To make ontologies useful, they must encompass a comprehensive domain view. To achieve ontology enrichment, there is a need to discover new concepts to be added, either b...
This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key symposia and workshops, it highlights the International Space Station (ISS) National Laboratory's r...
BACKGROUND: Delirium is a prevalent phenomenon among patients admitted to the geriatric intensive care unit (ICU) and can adversely impact prognosis and augment the risk of complications.
BACKGROUND: Machine learning (ML) and big data analytics are rapidly transforming health care, particularly disease prediction, management, and personalized care. With the increasing availability of real-world data (RWD) from diverse sources, such as...
BACKGROUND: Digital mental health tools promise to enhance the reach and quality of care. Current tools often recommend content to individuals, typically using generic knowledge-based systems or predictive artificial intelligence (AI). However, predi...
BACKGROUND: Colorectal cancer is now the leading cause of cancer-related deaths among young Americans. Accurate early prediction and a thorough understanding of the risk factors for early-onset colorectal cancer (EOCRC) are vital for effective preven...
BACKGROUND: Surgical consent forms convey critical information; yet, their complex language can limit patient comprehension. Large language models (LLMs) can simplify complex information and improve readability, but evidence of the impact of LLM-gene...
BACKGROUND: The rising prevalence of dementia necessitates a scalable solution to cognitive screening. Paper-based cognitive screening examinations are well-validated but minimally scalable. If a digital cognitive screening examination could replicat...
The past 25 years have seen the explosion of digital health care-from 1s and 0s initially serving most researchers for accomplishing their work, to the creation of smartphones, mHealth, and more recently artificial intelligence. The revolution for di...
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